Li-Zhou Fang*, Jian-Qing Zhang*, Ling Liu*, Wei-Ping Fu*, Jing-Kui Shu*, Jia-Gang Feng*, Xiao Liang†
Oncology Research, Vol.25, No.5, pp. 819-829, 2017, DOI:10.3727/096504016X14772349843854
Abstract Cancer stem cells (CSCs) are responsible for tumorigenesis and recurrence, so targeting CSCs is an effective
method to potentially cure cancer. BTB/POZ domain-containing protein 7 (Btbd7) has been found in various
cancers, including lung cancer and liver cancer, but the role of Btbd7 in non-small cell lung cancer (NSCLC),
CSC self-renewal, and chemoresistance is still unknown. Therefore, in this study we found that the ratio of
tumor sphere formation and stem cell transcription factors in CD133+
cells was dramatically enhanced compared to parental cells, which indicated successful sorting of CD133+
cells from A549. Meanwhile, Btbd7 and More >
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