A. NOEL GRAVINA^1,2, NOELIA D´ELÍA^1,2, LUCIANO A. BENEDINI^2,3,*, PAULA MESSINA^1,2

BIOCELL, Vol.48, No.11, pp. 1517-1520, 2024, DOI:10.32604/biocell.2024.055513 - 07 November 2024

Abstract This article navigates the relationship between biomaterials and osteogenic cell adhesion, highlighting the importance of mimicking the physiological response for bone tissue regeneration. Within this spirit is an initial description of the interaction between osteoblasts and osteoprogenitor cells with the extracellular matrix, explaining the leading role of integrins and cadherins in cell adhesion, and the intracellular signaling pathways elicited. Additionally, there is a focus on the strategies of advanced biomaterials that foster osteogenesis by replicating the native environment, taking advantage of these known specific signaling pathways. The final remarks lay on the need for careful More >

Ali S. Alghamdi^1,*, Mohamed A. Zohdy², Saad Aldoihi^3,4

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.2, pp. 1339-1370, 2024, DOI:10.32604/cmes.2024.048839 - 20 May 2024

Abstract In the contemporary era, the global expansion of electrical grids is propelled by various renewable energy sources (RESs). Efficient integration of stochastic RESs and optimal power flow (OPF) management are critical for network optimization. This study introduces an innovative solution, the Gaussian Bare-Bones Levy Cheetah Optimizer (GBBLCO), addressing OPF challenges in power generation systems with stochastic RESs. The primary objective is to minimize the total operating costs of RESs, considering four functions: overall operating costs, voltage deviation management, emissions reduction, voltage stability index (VSI) and power loss mitigation. Additionally, a carbon tax is included in… More >

YARA ALZGHOUL, HALA J. BANI ISSA, AHMAD K. SANAJLEH, TAQWA ALABDUH, FATIMAH RABABAH, MAHA AL-SHDAIFAT, EJLAL ABU-EL-RUB^*, FATIMAH ALMAHASNEH, RAMADA R. KHASAWNEH, AYMAN ALZU’BI, HUTHAIFA MAGABLEH

BIOCELL, Vol.48, No.4, pp. 559-569, 2024, DOI:10.32604/biocell.2024.048056 - 09 April 2024

Abstract Mesenchymal stem cells (MSCs) are ideal candidates for treating many cardiovascular diseases. MSCs can modify the internal cardiac microenvironment to facilitate their immunomodulatory and differentiation abilities, which are essential to restore heart function. MSCs can be easily isolated from different sources, including bone marrow, adipose tissues, umbilical cord, and dental pulp. MSCs from various sources differ in their regenerative and therapeutic abilities for cardiovascular disorders. In this review, we will summarize the therapeutic potential of each MSC source for heart diseases and highlight the possible molecular mechanisms of each source to restore cardiac function. More >

HUAN GAO^1,2, JIE ZHANG¹, TONY G. KLEIJN^1,3,4, ZHAOYONG WU⁵, BING LIU^1,6, YUJIN MA⁶, BAOYUE DING^1,*, DONGFENG YIN^2,*

Oncology Research, Vol.32, No.4, pp. 769-784, 2024, DOI:10.32604/or.2023.044276 - 20 March 2024

Abstract Bone metastasis secondary to breast cancer negatively impacts patient quality of life and survival. The treatment of bone metastases is challenging since many anticancer drugs are not effectively delivered to the bone to exert a therapeutic effect. To improve the treatment efficacy, we developed Pluronic P123 (P123)-based polymeric micelles dually decorated with alendronate (ALN) and cancer-specific phage protein DMPGTVLP (DP-8) for targeted drug delivery to breast cancer bone metastases. Doxorubicin (DOX) was selected as the anticancer drug and was encapsulated into the hydrophobic core of the micelles with a high drug loading capacity (3.44%). The… More > Graphic Abstract

HUAN HU^1,2,*, YUE HUANG¹, FANGZHOU LIU¹, QIAN WANG^1,2, YANZI YAO^3,*

BIOCELL, Vol.48, No.3, pp. 353-362, 2024, DOI:10.32604/biocell.2024.048311 - 15 March 2024

Abstract Increasing life expectancy and an aging population lead to age-related bone diseases like osteoporosis and low bone mass more prevalent. These conditions represent a common, costly and chronic burden, not only for elderly but also to society at large. Consequently, elucidating the pathophysiology and developing effective therapies for these diseases is of paramount importance. Recent advances in research have identified the gut as a novel and promising target for addressing bone disorders, giving rise to the concept of the “gut-bone axis”. An in-depth review of the latest insights into the effects of age-related physiological changes More >

Jinlong Yang, Kwang-Hee Lee, Chul-Hee Lee^*

CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.3, pp. 2917-2946, 2024, DOI:10.32604/cmes.2024.046740 - 11 March 2024

Abstract Cavitation is a common issue in pumps, causing a decrease in pump head, a fall in volumetric efficiency, and an intensification of outlet flow pulsation. It is one of the main hazards that affect the regular operation of the pump. Research on pump cavitation mainly focuses on mixed flow pumps, jet pumps, external spur gear pumps, etc. However, there are few cavitation studies on external herringbone gear pumps. In addition, pumps with different working principles significantly differ in the flow and complexity of the internal flow field. Therefore, it is urgent to study the cavitation… More >

Yanjun Yu¹, Lei Yu^1,*, Huiqi Wang², Haodong Zheng¹, Yi Deng¹

CMC-Computers, Materials & Continua, Vol.78, No.2, pp. 2225-2243, 2024, DOI:10.32604/cmc.2024.047641 - 27 February 2024

Abstract Bone age assessment (BAA) helps doctors determine how a child’s bones grow and develop in clinical medicine. Traditional BAA methods rely on clinician expertise, leading to time-consuming predictions and inaccurate results. Most deep learning-based BAA methods feed the extracted critical points of images into the network by providing additional annotations. This operation is costly and subjective. To address these problems, we propose a multi-scale attentional densely connected network (MSADCN) in this paper. MSADCN constructs a multi-scale dense connectivity mechanism, which can avoid overfitting, obtain the local features effectively and prevent gradient vanishing even in limited… More >

QINGJIAN HE¹, HUIXIN ZHU^2,3, SHANHONG FANG^4,5,*

BIOCELL, Vol.48, No.2, pp. 205-216, 2024, DOI:10.32604/biocell.2023.045109 - 23 February 2024

Abstract Introduction: Dexamethasone (Dex) caused impaired osteoblast differentiation and oxidative stress (OS) in bone marrow mesenchymal stem cells (BMSCs). This work sought to elucidate the precise molecular pathway through which Dex influences osteogenic differentiation (OD) and OS in BMSCs. Methods: The expression of Runt-related transcription factor 1 (RUNX1) and alpha-2 macroglobulin (A2M) was assessed in Dex-treated BMSCs using qRT-PCR and Western Blot. Following the functional rescue experiments, cell proliferation was determined by MTT assay, reactive oxygen species (ROS) expression by DCFH-DA fluorescent probe, lactate dehydrogenase (LDH), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (Gpx) expression… More >

MONA S. ABDELLATEIF^1,*, NAGLAA M. HASSAN², MAHMOUD M. KAMEL², YOMNA M. EL-MELIGUI²

Oncology Research, Vol.32, No.3, pp. 577-584, 2024, DOI:10.32604/or.2023.043026 - 06 February 2024

Abstract Background: microRNA-34a (miR-34a) had been reported to have a diagnostic role in acute myeloid leukemia (AML). However, its value in the bone marrow (BM) of AML patients, in addition to its role in response to therapy is still unclear. The current study was designed to assess the diagnostic, prognostic, and predictive significance of miR-34a in the BM of AML patients. Methods: The miR-34a was assessed in BM aspirate of 82 AML patients in relation to 12 normal control subjects using qRT-PCR. The data were assessed for correlation with the relevant clinical criteria, response to therapy,… More >

Sergio Henrique Gonçalves Motta¹, Ana Paula Ramos Soares¹, Juliana Campos Hasse Fernandes², Gustavo Vicentis Oliveira Fernandes^2,3,*

Journal of Renewable Materials, Vol.12, No.1, pp. 131-148, 2024, DOI:10.32604/jrm.2023.043940 - 23 January 2024

Abstract Bone biomaterials have been increasingly used to reconstruct maxillary atrophic ridges. Thus, the aim of this study was to evaluate bone reconstruction in the maxilla using a homologous cortico-cancellous FFB (lyophilized) graft and verify its reliability. Eight individuals were included from 2014 to 2018. The first surgery was performed to install homologous bone blocks in the maxilla. The period of the second intervention varied between 5 months and 15 days to 11 months (≈7.93 months). The biopsies were taken from the central region of the matured graft during the surgery for implant placement. All patients… More >