Syed Ayaz Ali Shah^1,*, Aamir Shahzad^1,*, Musaed Alhussein², Chuan Meng Goh³, Khursheed Aurangzeb², Tong Boon Tang⁴, Muhammad Awais⁵

CMC-Computers, Materials & Continua, Vol.79, No.2, pp. 2565-2583, 2024, DOI:10.32604/cmc.2024.047597 - 15 May 2024

Abstract Diagnosing various diseases such as glaucoma, age-related macular degeneration, cardiovascular conditions, and diabetic retinopathy involves segmenting retinal blood vessels. The task is particularly challenging when dealing with color fundus images due to issues like non-uniform illumination, low contrast, and variations in vessel appearance, especially in the presence of different pathologies. Furthermore, the speed of the retinal vessel segmentation system is of utmost importance. With the surge of now available big data, the speed of the algorithm becomes increasingly important, carrying almost equivalent weightage to the accuracy of the algorithm. To address these challenges, we present… More > Graphic Abstract

LEI WANG^1,2, ZHI-HANG WANG¹, NIAN-PING CAO¹, BOBO CHEN¹, CHONG-JUN HUANG¹, LEI YANG¹, YE TIAN^1,*

BIOCELL, Vol.48, No.2, pp. 191-203, 2024, DOI:10.32604/biocell.2023.045349 - 23 February 2024

Abstract Estrogen-related receptor alpha can significantly affect cell metabolism and play key regulatory roles in healthy and diseased organisms. ERRα is also related to the onset and progression of various cancer types. ERRα is primarily expressed in metabolically active tissues and regulates the transcription of metabolic genes in such tissues. It coordinates metabolism and energy demand, affects osteoblasts, osteoclasts, and chondrocytes, promotes muscle regeneration, participates in angiogenesis, and regulates cell aging. In this study, the literature related to the identification of ERRα in skeletal, muscular, and vascular systems was reviewed to further elucidate this receptor. More >

Shiyue Zhang¹, Xue Song^1,2, Jingying Wang^1,*, Wen Huang^3,*, Yue Zhou⁴, Mingrui Li¹

Molecular & Cellular Biomechanics, Vol.20, No.2, pp. 81-94, 2023, DOI:10.32604/mcb.2023.044445 - 01 November 2023

Abstract Pulmonary embolism (PE), caused by deep venous thrombosis (DVT), is a disease with high morbidity and mortality. Implantation of inferior vena cava filters is an important method for the clinical prevention of PE. The hemodynamic characteristics of filters implanted in the inferior vena cava (IVC) have a significant impact on their performance. However, IVC diameters vary among patients. This may have a direct impact on the hemodynamic properties of the filter. At present, there is no research on this kind of problem to be investigated. In this paper, the hemodynamic properties of the VenaTech convertible… More > Graphic Abstract

Abdullah O. Alamoudi^1,*, Sarah Mohammed Allabun²

CMC-Computers, Materials & Continua, Vol.75, No.1, pp. 2265-2281, 2023, DOI:10.32604/cmc.2023.032429 - 06 February 2023

Abstract Biomedical image processing is finding useful in healthcare sector for the investigation, enhancement, and display of images gathered by distinct imaging technologies. Diabetic retinopathy (DR) is an illness caused by diabetes complications and leads to irreversible injury to the retina blood vessels. Retinal vessel segmentation techniques are a basic element of automated retinal disease screening system. In this view, this study presents a novel blood vessel segmentation with deep learning based classification (BVS-DLC) model for DR diagnosis using retinal fundus images. The proposed BVS-DLC model involves different stages of operations such as preprocessing, segmentation, feature… More >

Nora Abdullah Alkhaldi^1,*, Hanan T. Halawani²

CMC-Computers, Materials & Continua, Vol.74, No.1, pp. 399-414, 2023, DOI:10.32604/cmc.2023.030872 - 22 September 2022

Abstract Automated segmentation of blood vessels in retinal fundus images is essential for medical image analysis. The segmentation of retinal vessels is assumed to be essential to the progress of the decision support system for initial analysis and treatment of retinal disease. This article develops a new Grasshopper Optimization with Fuzzy Edge Detection based Retinal Blood Vessel Segmentation and Classification (GOFED-RBVSC) model. The proposed GOFED-RBVSC model initially employs contrast enhancement process. Besides, GOAFED approach is employed to detect the edges in the retinal fundus images in which the use of GOA adjusts the membership functions. The More >

R. Nandakumar¹, P. Saranya^2,*, Vijayakumar Ponnusamy³, Subhashree Hazra², Antara Gupta²

Computer Systems Science and Engineering, Vol.45, No.1, pp. 279-292, 2023, DOI:10.32604/csse.2023.028703 - 16 August 2022

Abstract A prevalent diabetic complication is Diabetic Retinopathy (DR), which can damage the retina’s veins, leading to a severe loss of vision. If treated in the early stage, it can help to prevent vision loss. But since its diagnosis takes time and there is a shortage of ophthalmologists, patients suffer vision loss even before diagnosis. Hence, early detection of DR is the necessity of the time. The primary purpose of the work is to apply the data fusion/feature fusion technique, which combines more than one relevant feature to predict diabetic retinopathy at an early stage with… More >

Sonali Dash¹, Sahil Verma^2,*, Kavita², N. Z. Jhanjhi³, Mehedi Masud⁴, Mohammed Baz⁵

CMC-Computers, Materials & Continua, Vol.71, No.2, pp. 2459-2476, 2022, DOI:10.32604/cmc.2022.020904 - 07 December 2021

Abstract Segmentation of vessel in retinal fundus images is a primary step for the clinical identification for specific eye diseases. Effective diagnosis of vascular pathologies from angiographic images is thus a vital aspect and generally depends on segmentation of vascular structure. Although various approaches for retinal vessel segmentation are extensively utilized, however, the responses are lower at vessel's edges. The curvelet transform signifies edges better than wavelets, and hence convenient for multiscale edge enhancement. The bilateral filter is a nonlinear filter that is capable of providing effective smoothing while preserving strong edges. Fast bilateral filter is… More >

Hichem Guedri^1,*, Abdullah Bajahzar², Hafedh Belmabrouk³

CMES-Computer Modeling in Engineering & Sciences, Vol.127, No.1, pp. 59-77, 2021, DOI:10.32604/cmes.2021.013632 - 30 March 2021

Abstract In recent years, the three dimensional reconstruction of vascular structures in the field of medical research has been extensively developed. Several studies describe the various numerical methods to numerical modeling of vascular structures in near-reality. However, the current approaches remain too expensive in terms of storage capacity. Therefore, it is necessary to find the right balance between the relevance of information and storage space. This article adopts two sets of human retinal blood vessel data in 3D to proceed with data reduction in the first part and then via 3D fractal reconstruction, recreate them in More >

Shu Chien^*

Molecular & Cellular Biomechanics, Vol.16, No.3, pp. 163-178, 2019, DOI:10.32604/mcb.2019.07689

Abstract Professor Y.C. Fung has made tremendous impacts on science, engineering and humanity through his research and its applications, by setting the highest standards, through educating many students and their students, and providing his exemplary leadership. He has applied his profound knowledge and elegant analytical methods to the study of biomedical problems with rigor and excellence. He established the foundations of biomechanics in living tissues and organs. Through his vision of the power of “making models” to explain and predict biological phenomena, Dr. Fung opened up new vista for bioengineering, from organs-systems to molecules-genes, and has More >

Chetan Kuthe^∗, R. V. Uddanwadiker^†, P. M. Padole^‡, A. A. Ramteke^§

Molecular & Cellular Biomechanics, Vol.12, No.1, pp. 1-16, 2015, DOI:10.3970/mcb.2015.012.001

Abstract Skeletal muscles are responsible for the relative motion of the bones at the joints and provide the required strength. They exhibit highly nonlinear mechanical behaviour and are described by nonlinear hyperelastic constitutive relations. It is distinct from other biological soft tissue. Its hyperelastic or viscoelastic behaviour is modelled by using CE, SEE, and PEE. Contractile element simulates the behaviour of skeletal muscle when it is subjected to eccentric and concentric contraction. This research aims to estimate the stress induced in skeletal muscle in eccentric and concentric contraction with respect to the predefined strain. With the… More >