Jie Shen*, Jianhua Zhang†, Minhui Xiao*, Junfeng Yang*, Ningnan Zhang*
Oncology Research, Vol.26, No.8, pp. 1155-1165, 2018, DOI:10.3727/096504017X15041934685237
Abstract miR-203 is an epigenetically silenced tumor-suppressive microRNA in tumors. This study was designed to
investigate the effects of miR-203 on the proliferation, migration, invasion, and apoptosis of bladder cancer
(BCa) cells. The expression levels of miR-203 in BCa tissues, normal adjacent tissues, and BCa cell lines were
detected. BCa cells were transfected with miR-203 mimic and inhibitor to investigate the effect of miR-203 on
cell functions and the epithelial–mesenchymal transition (EMT). Cotransfection with miR-203 inhibitor and
shRNA of the predicted target gene Twist1 (si-Twist1) was performed to investigate the target relationship of
miR-203 and Twist1.… More >
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