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Search Results (16)
  • Open Access

    REVIEW

    Development of micro/nanostructured‒based biomaterials with biomedical applications

    AFAF ALHARTHI*

    BIOCELL, Vol.47, No.8, pp. 1743-1755, 2023, DOI:10.32604/biocell.2023.027154

    Abstract Natural biomaterials are now frequently used to build biocarrier systems, which can carry medications and biomolecules to a target region and achieve a desired therapeutic effect. Biomaterials and polymers are of great importance in the synthesis of nanomaterials. The recent studies have tended to use these materials because they are easily obtained from natural sources such as fungi, algae, bacteria, and medicinal plants. They are also biodegradable, compatible with neighborhoods, and non-toxic. Natural biomaterials and polymers are chemically changed when they are linked by cross linking agents with other polymers to create scaffolds, matrices, composites, and interpenetrating polymer networks employing… More >

  • Open Access

    ARTICLE

    Development and Characterisation of Phenolic Foams with Phenol-Formaldehyde-Chestnut Tannins Resin

    M.C. Lagel1, A. Pizzi1,2, S. Giovando3, A. Celzard4

    Journal of Renewable Materials, Vol.2, No.3, pp. 220-229, 2014, DOI:10.7569/JRM.2014.634113

    Abstract With the depletion of fossil resources, tannin extracts can be a natural alternative to some synthetic products. Hydrolysable chestnut tannin extracts have been used to partially replace phenol in PF resins for phenolic rigid foams. Phenol-formaldehyde-chestnut tannin (PFT) phenolic foams were initially made from copolymerized PFT resins of different molar ratio. The PFT foams so prepared were tested for thermal conductivity, these being slightly worse than that of pure PF foams; and for mechanical and water absorption, these two properties being better than those of pure PF foams. Indeed, PF resins represent an important part of synthetic resins. They are… More >

  • Open Access

    VIEWPOINT

    Mesenchymal stem cells, the secretome and biomaterials: Regenerative medicine application

    KI-TAEK LIM#,*, TEJAL V. PATIL#, DINESH K. PATEL, SAYAN DEB DUTTA, KEYA GANGULY, AAYUSHI RANDHAWA

    BIOCELL, Vol.46, No.10, pp. 2201-2208, 2022, DOI:10.32604/biocell.2022.020013

    Abstract Mesenchymal stem cells (MSCs) are multipotent cells usually isolated from bone marrow, endometrium, adipose tissues, skin, and dental pulp. MSCs played a crucial role in regenerative therapy and have been introduced as an interdisciplinary field between cell biology and material science. Recently, MSCs have been widely explored for their application in regenerative medicine and COVID-19 treatment. Different approaches to evaluate the future of biomaterials and stem cell properties have been developed. However, misconceptions and ethical issues still exist, such as MSCs being non-angiogenic, anti-apoptotic, and immunoregulatory competencies. Embryonic stem cells isolation primarily requires the consent of donors and can include… More >

  • Open Access

    VIEWPOINT

    Mesenchymal stem cells, secretome and biomaterials in in-vivo animal models: Regenerative medicine application in cutaneous wound healing

    MASSIMO CONESE1,*, AURELIO PORTINCASA2

    BIOCELL, Vol.46, No.8, pp. 1815-1826, 2022, DOI:10.32604/biocell.2022.019448

    Abstract The treatment of nonhealing and chronic cutaneous wounds still needs a clinical advancement to be effective. Both mesenchymal stem cells (MSCs), obtained from different sources, and their secretome derived thereof (especially exosomes) can activate signaling pathways related to promotion of cell migration, vascularization, collagen deposition, and inflammatory response demonstrating prohealing, angiogenetic and anti-scarring capacities. On the other hand, biodegradable biomimetic scaffolds can facilitate endogenous cell attachment and proliferation as well as extracellular matrix production. In this Review, we revise the complex composites made by biomimetic scaffolds, mainly hydrogels, and MSC-derived exosomes constructed for cutaneous wound healing. Studies demonstrate that there… More >

  • Open Access

    VIEWPOINT

    New paradigms in regenerative engineering: Emerging role of extracellular vesicles paired with instructive biomaterials

    W. BENTON SWANSON, YUJI MISHINA*

    BIOCELL, Vol.46, No.6, pp. 1445-1451, 2022, DOI:10.32604/biocell.2022.018781

    Abstract Mesenchymal stem cells (MSCs) have long been regarded as critical components of regenerative medicine strategies, given their multipotency and persistence in a variety of tissues. Recently, the specific role of MSCs in mediating regenerative outcomes has been attributed (in part) to secreted factors from transplanted cells, namely extracellular vesicles. This viewpoint manuscript highlights the promise of cell-derived extracellular vesicles as agents of regeneration, enhanced by synergy with appropriate biomaterials platforms. Extracellular vesicles are a potentially interesting regenerative tool to enhance the synergy between MSCs and biomaterials. As a result, we believe these technologies will improve patient outcomes through efficient therapeutic… More >

  • Open Access

    VIEWPOINT

    Dental-derived stem cells and biowaste biomaterials: What’s next in bone regenerative medicine applications

    MICHELE DI COSOLA1,§; STEFANIA CANTORE2,§,*; MARIO GIOSUÈ BALZANELLI3; CIRO GARGIULO ISACCO2,3; KIEU CAO DIEM NGUYEN2,3; RAJIV SAINI2; ANNARITA MALCANGI4; MARGHERITA TUMEDEI5; MARIATERESA AMBROSINO1; ANTONIO MANCINI2; SALVATORE SCACCO6; RICCARDO NOCINI7; LUIGI SANTACROCE2; ANDREA BALLINI8,9,#,*; EDOARDO BRAUNER10,#

    BIOCELL, Vol.46, No.4, pp. 923-929, 2022, DOI:10.32604/biocell.2022.018409

    Abstract The human teeth and oral cavity harbor various populations of mesenchymal stem cells (MSCs), so called dental-derived stem cells (D-dSCs) with self-renewing and multilineage differentiation capabilities. D-dSCs properties involves a strong paracrine component resulting from the high levels of bioactive molecules they secrete in response to the local microenvironment. Altogether, this viewpoint develops a general picture of current innovative strategies to employ D-dSCs combined with biomaterials and bioactive factors for regenerative medicine purposes, and offers information regarding the available scientific data and possible applications. More >

  • Open Access

    VIEWPOINT

    The versatility of mesenchymal stem cells: From regenerative medicine to COVID, what is next?

    THAÍS CASAGRANDE PAIM, MÁRCIA ROSÂNGELA WINK*

    BIOCELL, Vol.46, No.4, pp. 913-922, 2022, DOI:10.32604/biocell.2022.018498

    Abstract Mesenchymal stem cells (MSCs) play key roles in regenerative medicine by promoting tissue healing. MSCs can be isolated from different adult tissues and they are able to differentiate into several lineages. Due to their anti-inflammatory, angiogenic and immune-modulatory properties, MSCs are suitable for tissue engineering applications and, when associated with biomaterials, their benefits can be improved. Moreover, recently, MSCs have been studied for new clinical applications, such as in the treatment of patients with COVID-19. MSCs regenerative potential has been attributed to their secretome, which comprises extracellular matrix, soluble proteins and several elements, including the release of extracellular vesicles. Even… More >

  • Open Access

    REVIEW

    Potential Economic Value of Chitin and Its Derivatives as Major Biomaterials of Seafood Waste, with Particular Reference to Southeast Asia

    Hsiao Wei Tan1, Zhi Yin Joan Lim2, Nur Airina Muhamad3, Fong Fong Liew4,*

    Journal of Renewable Materials, Vol.10, No.4, pp. 909-938, 2022, DOI:10.32604/jrm.2022.018183

    Abstract With a growing population, changes in consumerism behavior and trends in consumption in Indo-Pacific Asia, our seafood processing and consumption practices produce a large volume of waste products. There are several advantages in regulating and sustaining shellfish processing industries. The major advantage of waste management is that it leads to better conservation of natural resources in the long run. Shrimp shell waste contains useful biomaterials, which are still untapped due to inadequate waste disposal and solid waste management. Chitin, the major component of shell waste, can be extracted either chemically or biologically. The chemical extraction approaches, which use acids and… More > Graphic Abstract

    Potential Economic Value of Chitin and Its Derivatives as Major Biomaterials of Seafood Waste, with Particular Reference to Southeast Asia

  • Open Access

    ARTICLE

    Composite Biomaterials Based on Poly(L-Lactic Acid) and Functionalized Cellulose Nanocrystals

    Mariia Stepanova1, Ilia Averianov1, Olga Solomakha1, Natalia Zabolotnykh2, Iosif Gofman1, Mikhail Serdobintsev2, Tatiana Vinogradova2, Viktor Korzhikov-Vlakh1,3, Evgenia Korzhikova-Vlakh1,3,*

    Journal of Renewable Materials, Vol.8, No.4, pp. 383-395, 2020, DOI:10.32604/jrm.2020.09206

    Abstract The biocomposite films were prepared from poly(L-lactic acid) and cellulose nanocrystals. To improve interfacial compatibility of hydrophilic cellulose nanocrystals with hydrophobic matrix polymer as well as to provide the osteoconductive properties, cellulose was functionalized with poly(glutamic acid). The modified cellulose nanocrystals were better distributed and less aggregated within the matrix, which was testified by scanning electron, optical and polarized light microscopy. According to mechanical tests, composites filled with nanocrystals modified with PGlu demonstrated higher values of Young’s modulus, elongation at break and tensile strength. Incubation of composite materials in model buffer solutions for 30 weeks followed with staining of Ca2+More >

  • Open Access

    ABSTRACT

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