CHENG-GONG LUO^1,2,#, JIAO ZHANG^1,#, YUN-ZHAO AN¹, XUAN LIU¹, SHUAI-JIE LI¹, WEI ZHANG¹, KAI LI¹, XU ZHAO¹, DONG-BO YUAN¹, LING-YUE AN¹, WEI CHEN², YE TIAN^1,*, BIN XU^1,*

BIOCELL, Vol.48, No.5, pp. 771-792, 2024, DOI:10.32604/biocell.2024.048878 - 06 May 2024

Abstract Background: Ferroptosis, a lipid peroxidation-mediated programmed cell death, is closely linked to tumor development, including prostate cancer (PCa). Despite established connections between ferroptosis and PCa, a comprehensive investigation is essential for understanding its impact on patient prognosis. Methods: A risk model incorporating four ferroptosis-related genes was developed and validated. Elevated risk scores correlated with an increased likelihood of biochemical recurrence (BCR), diminished immune infiltration, and adverse clinicopathological characteristics. To corroborate these results, we performed validation analyses utilizing datasets from both the Cancer Genome Atlas Cohort (TCGA) and the Gene Expression Synthesis Cohort (GEO). Moreover, we conducted… More >

Come Tholomier^1,2, Felix Couture^1,3, Khaled Ajib¹, Felix Preisser^4,5, Helen Davis Bondarenko¹, Cristina Negrean¹, Pierre Karakiewicz^1,4, Assaad El-Hakim⁶, Kevin C. Zorn¹

Canadian Journal of Urology, Vol.26, No.4, pp. 9843-9851, 2019

Abstract Introduction: Robotic-assisted radical prostatectomy (RARP) has grown to be the predominant global surgical approach to treat localized prostate cancer. However, there is still limited access to robotic technology and little data from Canadian cohorts. Herein, we report on our oncological and functional outcomes after 10 years of surgical experience.
Materials and methods: Prospective data from 1,034 RARP cases performed by two high-volume experienced surgeons at two academic centers were collected from October 2006 to June 2017. Preoperative characteristics, surgical, oncological, and functional outcomes were assessed up to 72 months postoperative.
Results: D’Amico risk distribution was 26.1%, 59.8%, and… More >

Avinash Chenam¹, Nora Ruel², Sumanta Pal³, John Barlog¹, Clayton Lau¹, Timothy Wilson¹, Bertram Yuh¹

Canadian Journal of Urology, Vol.25, No.3, pp. 9340-9348, 2018

Abstract Introduction: Extended lymph node dissection (ELND) compared to limited lymph node dissection (LLND) at the time of prostatectomy improves staging and lymph node (LN) yield. The effect on biochemical recurrence (BCR) and survival is less well understood. We sought to evaluate the benefit of robotic ELND and LLND with respect to BCR.
Materials and methods: Between 2008-2012, 584 consecutive men with intermediate or high-risk clinically localized adenocarcinoma of the prostate underwent robotic-assisted radical prostatectomy (RARP) with concomitant LLND (n = 326) or ELND (n = 258). Survival estimates were made using the Kaplan-Meier method. Log-rank statistic was… More >

Daniel Taussky^1,2, Felix Preisser^3,4, Pierre I. Karakiewicz^1,5, Derya Tilki^3,4, Carole Lambert^1,2, Jean-Paul Bahary^1,2, Guila Delouya^1,2, Robert Wistaff^2,6, Mikhael Laskine^2,6, Paul Van Nguyen^2,6, Madeleine Durand^2,6, Fred Saad⁵

Canadian Journal of Urology, Vol.25, No.5, pp. 9509-9515, 2018

Abstract Introduction: Conflicting data exists on the influence of metformin on prostate cancer. We investigated the importance of metformin in patients treated with radiotherapy or brachytherapy.
Materials and methods: All patients from a large institutionalized database, treated for primary localized prostate cancer with either brachytherapy or external-beam radiotherapy ± androgen deprivation therapy were identified. Groups were compared by Kaplan–Meier analyses and Cox regression models. Multivariate analysis was adjusted for CAPRA-Score, type of treatment, and age.
Results: A total of 2441 patients with complete data was identified. Among them, 382 patients (16% of total) were diabetic. Two hundred eighty-one of… More >

Daniel R. Jeske^1,2, Jenifer A. Linehan^3,4, Timothy G. Wilson^3,4, Mark H. Kawachi³, Kristina Wittig³, Katarzya Lamparska³, Camille Amparo³, Rosa Mejia³, Fang Lai⁵, Dimitra Georganopoulou⁵, Steven S. Smith³

Canadian Journal of Urology, Vol.24, No.6, pp. 9089-9097, 2017

Abstract Introduction: Early biochemical recurrence after prostate cancer surgery is associated with higher risk of aggressive disease and cancer specific death. Many new tests are being developed that will predict the presence of indicators of aggressive disease like early biochemical recurrence. Since recurrence occurs in less than 10% of patients treated for prostate cancer, validation of such tests will require expensive testing on large patient groups. Moreover, clinical application of the validated test requires that each new patient be tested. In this report we introduce a two-stage classifier system that minimizes the number of patients that must… More >

Yun-Sok Ha^1,2, Dong Il Kang³, Jeong Hyun Kim⁴, Jae Young Joung⁵, Jihyeong Yu⁶, Jaspreet S. Parihar¹, Amirali Hassanzadeh Salmasi¹, Shigeo Horie⁷, Wun-Jae Kim⁸, Isaac Yi Kim¹

Canadian Journal of Urology, Vol.21, No.3, pp. 7290-7297, 2014

Abstract Introduction: Positive surgical margin (PSM) has classically been associated with biochemical recurrence (BCR) following radical prostatectomy (RP) and immediate adjuvant radiotherapy has been advocated based on two large randomized prospective clinical studies. However, a significant percentage of patients with PSM never experience BCR. This study evaluated factors potentially affecting risk of BCR among the patients with PSM after robot-assisted radical prostatectomy (RARP).
Materials and methods: From a prospectively maintained database, 699 patients with localized prostate cancer who underwent a RARP without any adjuvant therapy were identified. Median follow up was 46.0 months. To determine the pathologic and… More >

Costas D. Lallas¹, Yomi Fashola¹, Robert B. Den², Francisco Gelpi-Hammerschmidt¹, Anne E. Calvaresi¹, Peter McCue³, Ruth Birbe³, Leonard G. Gomella¹, Edouard J. Trabulsi¹

Canadian Journal of Urology, Vol.21, No.5, pp. 7479-7486, 2014

Abstract Introduction: To identify and assess predictive factors for positive surgical margins (PSM) in patients undergoing radical prostatectomy (RP).
Materials and methods: An Institution Review Board (IRB) approved retrospective review of 1751 patients that underwent RP from March 2000 to June 2013 was performed. Identified were 1740 patients whom had not received neoadjuvant therapy; these were used for the purpose of this analysis. Univariate and multivariate analysis were performed to determine factors associated with and predictive of PSMs, divided into preoperative and pathological. Variables analyzed include age, body mass index (BMI), race, surgeon, surgical modality, pathologic T-stage and… More >

Bradley C. Carthon^1,2, David M. Marcus^2,3, Lindsey A. Herrel⁴, Ashesh B. Jani^2,3,4, Peter J. Rossi^2,3,4, Daniel J. Canter^2,4

Canadian Journal of Urology, Vol.20, No.3, pp. 6748-6755, 2013

Abstract Introduction: Radical prostatectomy is an effective primary treatment for clinically localized prostate cancer. While many patients are cured of their disease after surgery, there are still a significant proportion of men who will develop a biochemical recurrence (BCR). In this review, we detail existing treatment algorithms for this group of patients as well as future therapies that show great promise.
Materials and methods: A review of the literature was performed, and relevant, high-impact articles were identified and reviewed focusing on the treatment of men with BCR after surgery for prostate cancer. Wherever possible, we used data from… More >

Mark S. Soloway, Viacheslav Iremashvili, Michael A. Gorin, Ahmed Eldefrawy, Ramgopal Satyanarayana, Murugesan Manoharan

Canadian Journal of Urology, Vol.19, No.3, pp. 6280-6286, 2012

Abstract Introduction: The objective of this report is to describe the oncologic outcomes of men with margin-positive prostate cancer who were managed expectantly following radical prostatectomy.
Materials and methods: Between January 1992 and January 2011, 2166 men underwent an open radical prostatectomy by a single surgeon. Of these patients, 1592 (74%) had complete data and met the inclusion criteria of negative lymph nodes and no history of neoadjuvant or adjuvant therapy. This cohort was dichotomized by the presence or absence of at least one positive surgical margin. Groups were compared for differences in recurrence-free and overall survival.
Results: In… More >

Gary W. Bong, Thomas E. Keane

Canadian Journal of Urology, Vol.14, Suppl.6, pp. 2-9, 2007

Abstract Despite excellent success rates with radical prostatectomy and radiotherapy for the treatment of prostate cancer, a significant number of patients will experience a rise in their serum prostate specific antigen (PSA) level. A variety of salvage options in this scenario have been investigated and the choice to pursue surveillance, single therapy or combination therapy depends on clinical assessment of risk and location of tumor recurrence. After radical prostatectomy, for example, patients with low risk local disease may not require secondary therapy or may benefit from salvage radiotherapy. Those with higher risk disease, based on PSA More >