Huan Shen*1, Li Liu†1, Yongjin Yang*, Wenxing Xun‡, Kewen Wei‡, Guang Zeng‡
Oncology Research, Vol.25, No.7, pp. 1141-1152, 2017, DOI:10.3727/096504017X14841698396784
Abstract Oral squamous cell carcinoma (OSCC) is a common cancer of the head and neck. Betulinic acid (BA) is a naturally occurring pentacyclic triterpenoid. The present study was designed to explore the effects of BA on OSCC
KB cell proliferation in vitro and on implanted tumor growth in vivo and to examine the possible molecular mechanisms. The results showed that BA dose-dependently inhibited KB cell proliferation and decreased
implanted tumor volume. In addition, BA significantly promoted mitochondrial apoptosis, as reflected by an
increase in TUNEL+
cells and the activities of caspases 3 and 9, an increase… More >
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