Vinay Durbhakula^1,*, Ziv Savin¹, Einat Savin-Shalom², Stephanie L. Gold², Kavita Gupta¹, Eve Frangopoulos¹, Blair Gallante¹, William M. Atallah¹, Mantu Gupta¹

Canadian Journal of Urology, Vol.32, No.6, pp. 659-668, 2025, DOI:10.32604/cju.2025.067614 - 30 December 2025

Abstract Background: A well-established correlation exists between Inflammatory Bowel Disease (IBD) and urolithiasis. However, the influence of surgical history on the severity of urolithiasis in IBD patients remains underexplored. This study aims to investigate the association between gastrointestinal (GI) bowel resection and urolithiasis severity in patients with IBD. Methods: This retrospective cohort study analyzed 42 patients diagnosed with both IBD and urolithiasis between 2016 and 2024. Patients were categorized based on their history of bowel resection. Primary outcomes included maximal stone burden, need for urolithiasis surgery, and stone recurrence. Secondary outcomes were stone-related clinical events, multiple… More >

Gloria Krajnc¹, Lara Metlika², Uroš Potočnik^1,2,3, Boris Gole^2,*

BIOCELL, Vol.49, No.6, pp. 991-1017, 2025, DOI:10.32604/biocell.2025.063486 - 24 June 2025

Abstract Vedolizumab is a humanized monoclonal antibody and one of the safest biologics for the treatment of both forms of inflammatory bowel disease (IBD)-Crohn’s disease and ulcerative colitis. It targets the α4β7 integrin and blocks leukocyte trafficking to the gut. Regardless of its efficacy in many patients, non-response to vedolizumab treatment poses a significant clinical challenge. In this review, we synthesize recent findings on genomic, transcriptomic, proteomic, and cellular biomarkers of vedolizumab response, emphasizing their roles in predicting therapeutic outcomes and understanding non-responsiveness. Key insights include the identification of epigenetic and transcriptomic signatures, the involvement of More >

Benjamin J. Lichtbroun^1,2,*, Mann Patel², Alexis Consalvo², Labeeqa Khizir², Munisa Said², Austin Chien², Kevin Chua^1,2, John Pfail^1,2, Rachel Passarelli^1,2, Vignesh T. Packiam¹, David Golombos¹, Sammy Elsamra², Thomas L. Jang¹, Arnav Srivastava^1,3, Saum Ghodoussipour¹

Canadian Journal of Urology, Vol.32, No.1, pp. 55-62, 2025, DOI:10.32604/cju.2025.064701 - 20 March 2025

Abstract Introduction: Infections are the most feared complication of transrectal prostate biopsies, along with growing concerns of antibiotic resistance. Our institution transitioned to a transperineal approach without use of perioperative antibiotics or bowel preparations. We aimed to compare the safety outcomes associated with transperineal and transrectal prostate biopsy techniques. Materials and Methods: A retrospective analysis of patients who underwent transrectal and transperineal prostate biopsies at our institution from 2019–2022 was performed. Results: We identified 319 patients—174 transrectal and 145 transperineal. 8 patients who had transperineal biopsy (5.5%) received peri-operative antibiotics, compared to 100% with transrectal biopsy. 35.86%… More >

AHMAD SHAHIR MOHAMAD NAZRI, NAZIHAH MOHD YUNUS, MARAHAINI MUSA^*

BIOCELL, Vol.49, No.1, pp. 149-160, 2025, DOI:10.32604/biocell.2024.057352 - 24 January 2025

Abstract Pediatric inflammatory bowel disease (IBD) is a chronic and heterogeneous disease. IBD is commonly classified into Crohn’s disease and ulcerative colitis. It is linked to serious symptoms and complications. The onset of IBD commonly occurs during adolescence. Despite the significant number of cases globally (~5 million), the causes of pediatric IBD, which constitutes 25% of IBD patients, are not yet fully understood. Apart from environmental factors, genetic factors contribute to a higher risk of developing IBD. The predisposition risk of IBD can be investigated using genetic testing. Genetic mechanisms of pediatric IBD are highly complex More >

Lihui Ma¹, Wei Li¹, Yuanyuan Wang¹, Pan Zhang¹, Lina Wang¹, Xinying Liu¹, Meiqin Dong², Xuewen Cao², Jiang Bian^3,*

FDMP-Fluid Dynamics & Materials Processing, Vol.21, No.1, pp. 107-119, 2025, DOI:10.32604/fdmp.2024.058295 - 24 January 2025

Abstract Gas-liquid flow (GLF), especially slug and annular flows in oil and gas gathering and transportation pipelines, become particularly complex inside elbows and can easily exacerbate pipeline corrosion and damage. In this study, FLUENT was used to conduct 3D simulations of slug and annular flow in elbows for different velocities to assess the ensuing changes in terms of pressure. In particular, the multifluid VOF (Volume of Fraction) model was chosen. The results indicate that under both slug and annular flow conditions, the pressure inside the elbow is lower than the outside. As the superficial velocity More >

Wei Zhuang, Zhen Li

European Cytokine Network, Vol.34, No.4, pp. 46-53, 2023, DOI:10.1684/ecn.2023.0489

Abstract Background: There is currently no safe or effective treatment for inflammatory bowel disease (IBD), which is defined as recurrent and persistent intestinal inflammation. Thymic stromal lymphopoietin (TSLP) has been shown to be associated with the pathogenesis of IBD, and the JAK2/STAT5 signalling pathway has demonstrated much promise as a novel therapeutic target for IBD. Materials and Methods: In this study, we first evaluated levels of TSLP in dextran sodium sulphate (DSS)-induced IBD mice. Second, we applied tezepelumab, an anti-TSLP monoclonal antibody (20 µg per mouse, intraperitoneally), to DSS-induced IBD mice and quantified the signs of histopathological change,… More >

Leonard G. Gomella

Canadian Journal of Urology, Vol.30, No.4, pp. 11583-11583, 2023

Abstract This article has no abstract. More >

Emad Ul Haq Qazi^1,*, Tanveer Zia¹, Muhammad Imran², Muhammad Hamza Faheem¹

Intelligent Automation & Soft Computing, Vol.38, No.3, pp. 225-240, 2023, DOI:10.32604/iasc.2023.041181 - 27 February 2024

Abstract Deep learning is considered one of the most efficient and reliable methods through which the legitimacy of a digital image can be verified. In the current cyber world where deepfakes have shaken the global community, confirming the legitimacy of a digital image is of great importance. With the advancements made in deep learning techniques, now we can efficiently train and develop state-of-the-art digital image forensic models. The most traditional and widely used method by researchers is convolution neural networks (CNN) for verification of image authenticity but it consumes a considerable number of resources and requires… More >

ZEPENG DONG, CHENYE ZHAO, SHIBO HU, KUI YANG, JUNHUI YU^*, XUEJUN SUN, JIANBAO ZHENG^*

BIOCELL, Vol.47, No.12, pp. 2735-2745, 2023, DOI:10.32604/biocell.2023.043422 - 27 December 2023

Abstract Objectives: Angiogenesis plays a significant role in the occurrence and development of inflammatory bowel disease (IBD). The aim of this study is to explore potential angiogenesis related genes (ARGs) in IBD through bioinformatics analysis and in vivo experiments. Methods: GSE57945, GSE87466, and GSE36807 were obtained from the Gene Expression Omnibus database. GSE57945 was used as the training set, while GSE87466 and GSE36807 were used as the validation set. The key ARGs associated with IBD were identified using the least absolute shrinkage and selection operator (LASSO) and random forest methods. These identified ARGs were then utilized to construct… More >

AMYLLY SANUELLY DA PAZ MARTINS^1,#, MARLA DE CERQUEIRA ALVES^2,#, ORLANDO ROBERTO PIMENTEL DE ARAÚJO³, FABIANA OLIVEIRA DOS SANTOS CAMATARI⁴, MARÍLIA OLIVEIRA FONSECA GOULART^1,3,5, FABIANA ANDRÉA MOURA^2,6,*

BIOCELL, Vol.47, No.11, pp. 2547-2566, 2023, DOI:10.32604/biocell.2023.043253 - 27 November 2023

Abstract

Curcumin, a natural product, has exhibited promising effects in both animal models and clinical trials, interacting with a multitude of factors linked to Inflammatory Bowel Disease (IBD). These factors encompass cytokines, oxidative stress-associated enzymes, and modulation of the intestinal microbiota. Notably, curcumin has demonstrated therapeutic potential in animal models of colitis, wherein it exerts a negative regulatory influence on pivotal signaling pathways such as PI3/Akt, JAK/STAT, and β-catenin. Moreover, it inhibits the expression of pro-inflammatory enzymes and co-stimulatory molecules (including RANKL, ICAM-1, CD205, CD256, TLR4, among others), while curbing immune cell chemotaxis, thereby attenuating the characteristic

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