Osama M. AHMED1, Mohamed A. HASSAN2, Ablaa S. SALEH2
BIOCELL, Vol.44, No.1, pp. 27-29, 2020, DOI:10.32604/biocell.2020.08040
- 01 March 2020
Abstract This study aimed to assess the effect of hesperetin and/or bone marrow-derived mesenchymal stem cells
(BM-MSCs) on disturbed lipid profile, heart and kidney functions, oxidative stress and antioxidant defense system
in streptozotocin (STZ)-induced diabetic rats. Type 1 diabetes mellitus (T1DM) was induced in male Wistar rats by
injecting 40 mg/kg body weight (b.w.) STZ dissolved in citrate buffer (pH 4.5). The diabetic rats were treated with
hesperetin orally administered at dose 20 mg/kg b.w., BM-MSCs intravenously injected at a dose of 1 x 106 cells/
rat/week and their combination for 6 weeks. The diabetic rats… More >
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