Zhiguo Wang*†1,
Zehui Fang‡1,
Runzhang Lu†, Hongli Zhao‡, Tiejun Gong†,
Dong Liu†, Luojia Hong‡, Jun Ma†, Mei Zhang*
Oncology Research, Vol.27, No.9, pp. 1035-1042, 2019, DOI:10.3727/096504019X15528367532612
Abstract Although arsenic trioxide (ATO) is a well-known antileukemic drug used for acute promyelocytic leukemia
treatment, the development of ATO resistance is still a big challenge. We previously reported that microRNA-
204 (miR-204) was involved in the regulation of acute myeloid leukemia (AML) cell apoptosis, but its role
in chemoresistance is poorly understood. In the present study, we showed that miR-204 was significantly
increased in AML cells after ATO treatment. Interestingly, the increased miR-204 level that was negatively correlated with ATO induced the decrease in cell viability and baculoviral inhibition of apoptosis protein repeatcontaining 6 (BIRC6)… More >
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