LING MA^1,#, ZIRUI JIANG^1,#, XIAO HOU¹, YUTING XU¹, ZIYUN CHEN¹, SIYI ZHANG¹, HANXUE LI¹, SHAOJIE MA¹, GENG ZHANG², XIUJUN WANG^1,*, JING JI^1,*

BIOCELL, Vol.48, No.5, pp. 847-860, 2024, DOI:10.32604/biocell.2024.050868 - 06 May 2024

Abstract Background: Regulatory proteins involved in human cellular division and proliferation, cyclin-dependent kinases 4 and 6 (CDK4/6) are overexpressed in numerous cancers, including triple-negative breast cancer (TNBC). TNBC is a common pathological subtype of breast cancer that is prone to recurrence and metastasis, and has a single treatment method. As one of the CDK4/6 inhibitors, abemaciclib can effectively inhibit the growth of breast tumors. In this study, we synthesized LA-D-B1, a derivative of Abemaciclib, and investigated its anti-tumor effects in breast cancer. Methods: Cellular viability was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cell cloning and… More >

Jai Hak Park^*

Digital Engineering and Digital Twin, Vol.2, pp. 79-101, 2024, DOI:10.32604/dedt.2024.047280 - 25 March 2024

Abstract A finite element alternating method has been known as a very convenient and accurate method to solve two and three-dimensional crack problems. In this method, a general crack problem is solved by a superposition of two solutions. One is a finite element solution for a finite body without a crack, and the other is an analytical solution for a crack in an infinite body. Since a crack is not considered in a finite element model, generating a model is very simple. The method is especially very convenient for a fatigue crack growth simulation. Over the More >

Hasna Akarni^*, Hamza Mabchour, Laila El Aarabi, Soumia Mordane

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.3, pp. 579-593, 2024, DOI:10.32604/fdmp.2023.043080 - 12 January 2024

Abstract In this study, we focus on the numerical modelling of the interaction between waves and submerged structures in the presence of a uniform flow current. Both the same and opposite senses of wave propagation are considered. The main objective is an understanding of the effect of the current and various geometrical parameters on the reflection coefficient. The wave used in the study is based on potential theory, and the submerged structures consist of two rectangular breakwaters positioned at a fixed distance from each other and attached to the bottom of a wave flume. The numerical More >

Menghui Liang¹, Changjun Zheng^1,*, Yongbin Zhang¹, Chuanxing Bi¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.27, No.1, pp. 1-1, 2023, DOI:10.32604/icces.2023.09605

Abstract This paper presents an accurate and efficient indirect boundary element method (IBEM) accelerated by the fast multipole algorithm (FMA)for the design sensitivity analysis of large-scale thin-body acoustic problems above an infinite impedance plane. The non-uniqueness issue of the IBEM in solving exterior acoustic problems is avoided by applying a hybrid combination of single- and double-layer potentials. The half-space impedance Green’s function which involves an image complex line source and is valid for both mass-like and spring-like impedance plane is employed to involve the sound-absorbing effect of the ground surface. Explicit evaluation formulations of the singular More >

Dan Li¹, Jie Wang¹, Haibo Chen^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.26, No.4, pp. 1-2, 2023, DOI:10.32604/icces.2023.09139

Abstract In practical vibro-acoustic problems, the external excitation normally contains a certain frequency band structure [1]. Therefore, it is needed to perform optimization under frequency band analysis. For sound radiation problems caused by structural vibration, a topology optimization method for structural materials is proposed based on the acoustic-vibration coupling analysis [2-6] and the frequency-band matrix interpolation method [7,8]. By combining the advantages of FEM and BEM in structural and acoustic field analysis, the accurate solution of the acoustic-vibration coupling problem is achieved. The structural material interpolation model is established using the solid isotropic material with penalization… More >

Yanming Xu^1,2, Leilei Chen^1,2,*, Haojie Lian³

The International Conference on Computational & Experimental Engineering and Sciences, Vol.26, No.1, pp. 1-1, 2023, DOI:10.32604/icces.2023.010581

Abstract An isogeometric coupling algorithm based on the finite element method and the boundary element method (IGA-FEM/BEM) is proposed for the simulation of acoustic fluid-structure interaction and structuralacoustic topology optimization using the direct differentiation method. The geometries are constructed from triangular control meshes through Loop subdivision scheme. The effect of sound-absorbing materials on the acoustic response is characterized by acoustic impedance boundary conditions. The optimization problem is formulated in the framework of Solid Isotropic Material with Penalization methods and the sound absorption coefficients on elements are selected as design variables. Numerical examples are presented to demonstrate More >

Kusnandar¹, Win-Jet Luo^1,2, Indra Permana¹, Fu-Jen Wang^2,*, Gantulga Bayarkhuu²

Energy Engineering, Vol.120, No.6, pp. 1387-1399, 2023, DOI:10.32604/ee.2023.027459 - 03 April 2023

Abstract The heating, ventilating, and air conditioning (HVAC) system consumes nearly 50% of the building’s energy, especially in Taiwan with a hot and humid climate. Due to the challenges in obtaining energy sources and the negative impacts of excessive energy use on the environment, it is essential to employ an energy-efficient HVAC system. This study conducted the machine tools building in a university. The field measurement was carried out, and the data were used to conduct energy modelling with EnergyPlus (EP) in order to discover some improvements in energy-efficient design. The validation between field measurement and… More >

Yi Sun^1,2,*, Chihua Lu^1,2, Zhien Liu^1,2, Menglei Sun¹, Hao Chen¹

CMES-Computer Modeling in Engineering & Sciences, Vol.135, No.3, pp. 2307-2330, 2023, DOI:10.32604/cmes.2023.025313 - 23 November 2022

Abstract In automotive industries, panel acoustic contribution analysis (PACA) is used to investigate the contributions of the body panels to the acoustic pressure at a certain point of interest. Currently, PACA is implemented mostly by either experiment-based methods or traditional numerical methods. However, these schemes are effort-consuming and inefficient in solving engineering problems, thereby restraining the further development of PACA in automotive acoustics. In this work, we propose a PACA scheme using discontinuous isogeometric boundary element method (IGABEM) to build an easily implementable and efficient method to identify the relative acoustic contributions of each automotive body… More >

Anchal Tyagi¹, Salem Alelyani², Sapna Katiyar³, Mohammad Rashid Hussain^2,*, Rijwan Khan³, Mohammed Saleh Alsaqer²

Computer Systems Science and Engineering, Vol.45, No.2, pp. 1423-1438, 2023, DOI:10.32604/csse.2023.026057 - 03 November 2022

Abstract An image can be degraded due to many environmental factors like foggy or hazy weather, low light conditions, extra light conditions etc. Image captured under the poor light conditions is generally known as non-uniform illumination image. Non-uniform illumination hides some important information present in an image during the image capture Also, it degrades the visual quality of image which generates the need for enhancement of such images. Various techniques have been present in literature for the enhancement of such type of images. In this paper, a novel architecture has been proposed for enhancement of poor… More >

Mohamed Abdelsabour Fahmy^1,2,*

CMC-Computers, Materials & Continua, Vol.69, No.1, pp. 931-944, 2021, DOI:10.32604/cmc.2021.018191 - 04 June 2021

Abstract The main objective of this paper is to introduce a new theory called size-dependent thermopiezoelectricity for smart nanostructures. The proposed theory includes the combination of thermoelastic and piezoelectric influences which enable us to describe the deformation and mechanical behaviors of smart nanostructures subjected to thermal, and piezoelectric loadings. Because of difficulty of experimental research problems associated with the proposed theory. Therefore, we propose a new boundary element method (BEM) formulation and algorithm for the solution of such problems, which involve temperatures, normal heat fluxes, displacements, couple-tractions, rotations, force-tractions, electric displacement, and normal electric displacement as… More >