Christine G. Roth*, Amanda Gillespie-Twardy†, Stanley Marks†, Mounzer Agha†, Anastasios Raptis†, Jing-Zhou Hou†, Rafic Farah†, Yan Lin§, Ying Qian§, Liron Pantanowitz‡, Michael Boyiadzis†
Oncology Research, Vol.23, No.3, pp. 137-146, 2015, DOI:10.3727/096504015X14500972666761
Abstract “Double” or “triple” hit lymphomas (D/THL) with recurrent translocations involving MYC/8q24 and
BCL2/18q21 and/or BCL6/3q27 are characterized by a poor prognosis, but their identification is hampered
by the clinicopathologic overlap with other disease categories. Cases with circulating blastic-appearing
cells may initially cause concern for lymphoblastic leukemia a diagnostic dilemma, which has not been
well studied. There is only limited literature regarding the flow cytometric (FC) D/THL phenotype and its
clinical correlates. The FC features of 20 D/THL (11 BCL2+/MYC+, 5 BCL6+/MYC+, 4 BCL2+/BCL6+/MYC+)
were evaluated, compared to 20 B-lymphoblastic leukemias (B-LBL), and correlated with overall survival.
Most (89%,… More >
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