Jing Shan¹, Catherine King^2,3, Harunor Rashid^3,4, Veysel Kayser^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070851 - 30 December 2025

Abstract Objectives: B-cell maturation antigen (BCMA)-targeted antibody–drug conjugates (ADCs) have emerged as promising therapies for relapsed/refractory multiple myeloma (RRMM), but the overall efficacy and safety profile is unclear. This study aimed to synthesize the available evidence on the safety and efficacy of BCMA-ADCs in development for RRMM. Methods: A systematic search was conducted using six bibliographic databases and ClinicalTrials.gov up to November 2024. Studies were eligible if they were human clinical trials or animal studies evaluating BCMA-ADCs and reported efficacy and safety outcomes. Data extraction and quality assessments were conducted using validated tools, including ROBINS-I… More >

Xia Yan¹, Wei Wang¹, Kai Shen^2,*, Yanqing Feng¹, Junyi Sun¹, Xiaogang Li¹, Wentao Zhu¹, Binbin Shi¹, Guanglong Sheng^2,3

Energy Engineering, Vol.123, No.1, 2026, DOI:10.32604/ee.2025.070360 - 27 December 2025

Abstract In the development of coalbed methane (CBM) reservoirs using multistage fractured horizontal wells, there often exist areas that are either repeatedly stimulated or completely unstimulated between fracturing stages, leading to suboptimal reservoir performance. Currently, there is no well-established method for accurately evaluating the effectiveness of such stimulation. This study introduces, for the first time, the concept of the Fracture Network Bridging Coefficient (FNBC) as a novel metric to assess stimulation performance. By quantitatively coupling the proportions of unstimulated and overstimulated volumes, the FNBC effectively characterizes the connectivity and efficiency of the fracture network. A background… More >

Song Xu^1,2,3,4,5,*, Mengxin Lu^1,2,3,4,5, Zhonghua Yang^1,2,3,4,5, Hang Zheng^1,2,3,4,5

Canadian Journal of Urology, Vol.32, No.6, pp. 579-588, 2025, DOI:10.32604/cju.2025.063069 - 30 December 2025

Abstract Background: Many studies have evaluated the performance of fluorescence in situ hybridization (FISH) in detecting urothelial carcinoma, while few of them compared it in detecting bladder cancer (BC) vs. upper tract urothelial carcinoma (UTUC). This study aimed to determine and compare the FISH performance in detecting BC and UTUC. Methods: Data of patients with suspected urothelial carcinoma (UC) who accepted FISH from January 2021 to April 2023 were retrieved. The sensitivity and specificity of FISH in detecting BC and UTUC were determined and compared. Results: A total of 145 BC, 62 UTUC, and 170 non-UC patients were… More >

Mirza Murad Baig¹, Muhammad Rehan Faheem^2,*, Lal Khan^3,*, Hannan Adeel², Syed Asim Ali Shah⁴

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.3, pp. 2895-2935, 2025, DOI:10.32604/cmes.2025.073172 - 23 December 2025

Abstract With growing urban areas, the climate continues to change as a result of growing populations, and hence, the demand for better emergency response systems has become more important than ever. Human Behaviour Classification (HBC) systems have started to play a vital role by analysing data from different sources to detect signs of emergencies. These systems are being used in many critical areas like healthcare, public safety, and disaster management to improve response time and to prepare ahead of time. But detecting human behaviour in such stressful conditions is not simple; it often comes with noisy… More > Graphic Abstract

Kayce Blumenstock^1,2, Vandana Zaman^2,3, Camille Green³, Narendra L. Banik^1,2,3, Azizul Haque^1,2,3,*

BIOCELL, Vol.49, No.10, pp. 1859-1871, 2025, DOI:10.32604/biocell.2025.068773 - 22 October 2025

Abstract Fc Receptor-Like 1 (FCRL1), a member of the FCRL family, contains two immunoreceptor tyrosine-based activation motifs (ITAMs) in its cytoplasmic domain and plays a critical role in B-cell biology. Its expression begins in pre-B-cells, dynamically shifts during B-cell development, and contributes to the regulation of human B-cell activation. Notably, FCRL1 is overexpressed in subsets of naive and memory B-cells, as well as in malignant B-cells, including those in diffuse large B-cell lymphoma (DLBCL), an aggressive and often treatment-resistant hematological malignancy. Among FCRL family members, FCRL1 stands out as a promising immunotherapeutic target due to its More >

Li Yu^1,2,3, Xiaoyan Zhang^1,2, Yan Feng^1,4, Xinyue Liao^1,4, Tiejun Zhou⁵, Hang Si^1,4, Yun Feng^1,4, Decai Wang^6,*, Yongxian Lai^1,7,*

Oncology Research, Vol.33, No.8, pp. 2037-2053, 2025, DOI:10.32604/or.2025.064276 - 18 July 2025

Abstract Background: Oral squamous cell carcinoma (OSCC) is the most common head and neck malignancy with a low five-year survival rate. ATP-binding cassette subfamily B member 5 (ABCB5) has been linked to tumorigenesis. However, its role in inducing OSCC remains unclear. Methods: Quantitative reverse transcription polymerase chain reaction (qRT-PCR), western blot, and immunocytochemistry (ICC) were performed to examine the level of ABCB5 in OSCC (CAL27 and HSC-3) and human oral keratinocyte (HOK). ABCB5 was knocked down in CAL27 cells using ABCB5-specific small interfering RNA (ABCB5 siRNA), and its contribution to migration, invasion, and epithelial-mesenchymal transition (EMT),… More >

Weiwei Chen¹, Xiaodie Zhou², Huiyu Li¹, Yuchen Yang¹, Lu Lu¹, Chunyan Zhu¹, Rong Fang¹, Xiaoyuan Chu¹, Shuping Zhou^3,*, Qian Sun^1,*

Oncology Research, Vol.33, No.8, pp. 2123-2139, 2025, DOI:10.32604/or.2025.063484 - 18 July 2025

Abstract Background: Primary bone marrow diffuse large B-cell lymphoma (PBM-DLBCL) represents an uncommon yet clinically aggressive hematologic malignancy. Despite its significant clinical impact, this entity lacks standardized diagnostic criteria in current WHO classifications. Methods: We performed a retrospective analysis of 55 PBM-DLBCL cases from our institutional database and published literature (2001–2022) to characterize disease features and identify prognostic factors, with particular focus on assessing how different treatment regimens influence therapeutic efficacy and long-term outcomes. Results: The data suggested a potential link between international prognostic index (IPI) scores and poorer survival, albeit without conclusive statistical evidence (p = More >

Zhun Yu^1,2, Jie Wang^1,2, Guoping Xu^1,2,*

Oncology Research, Vol.33, No.8, pp. 2013-2035, 2025, DOI:10.32604/or.2025.061757 - 18 July 2025

Abstract Objectives: Triple-negative breast cancer (TNBC) presents a major treatment challenge due to its aggressive behavior. The dysfunction of the Golgi apparatus (GA) contributes to the development of various cancers. This study aimed to utilize GA-related genes (GARGs) to forecast the prognosis and immune profile of TNBC. Methods: The data were downloaded from The Cancer Genome Atlas (TCGA) database, including 175 TNBC and 99 healthy samples. The differentially expressed GARGs (DEGARGs) were analyzed using the TCGA biolinks package. The patients with TNBC were classified into two clusters utilizing the ConsensusClusterPlus package according to prognosis-related DEGARGs, followed by… More >

Mohammed Althubyani^1,*, Nidal E. Taha², Khdija O. Taha², Rasmiyah A. Alharb², Sayed Saber^1,3

CMES-Computer Modeling in Engineering & Sciences, Vol.143, No.3, pp. 3491-3521, 2025, DOI:10.32604/cmes.2025.061640 - 30 June 2025

Abstract This study investigates the dynamics of pneumococcal pneumonia using a novel fractal-fractional Susceptible-Carrier-Infected-Recovered model formulated with the Atangana-Baleanu in Caputo (ABC) sense. Unlike traditional epidemiological models that rely on classical or Caputo fractional derivatives, the proposed model incorporates nonlocal memory effects, hereditary properties, and complex transmission dynamics through fractal-fractional calculus. The Atangana-Baleanu operator, with its non-singular Mittag-Leffler kernel, ensures a more realistic representation of disease progression compared to classical integer-order models and singular kernel-based fractional models. The study establishes the existence and uniqueness of the proposed system and conducts a comprehensive stability analysis, including local More >

QIAN LI^1,#, SHUNPENG ZHU^1,#, MINGXIAN ZHU², FANG WANG^1,*, JINHUA ZHOU^1,*

Oncology Research, Vol.33, No.7, pp. 1757-1767, 2025, DOI:10.32604/or.2025.062539 - 26 June 2025

Abstract Objectives: Our previous research demonstrated that SIC-19, an innovative inhibitor of salt-inducible kinase 2 (SIK2), effectively reduces SIK2 protein levels through the ubiquitin-proteasome pathway and exhibits synthetic lethal effects with poly ADP-ribose polymerase (PARP) inhibitors in ovarian cancer. However, the role of SIC-19 in triple-negative breast cancer (TNBC) and pancreatic cancer (PC) remains poorly defined. This study aims to investigate whether SIC-19 combined with PARP inhibitors can induce synthetic lethal effects in TNBC and PC. Methods: Cell lines with high SIK2 expression were identified through Western blot analysis. The combination’s impact was evaluated using Cell… More >