Haoran Wu1, Xugang Wang1, Naixin Mo, Liang Zhang, Xiaoliang Yuan, Zhong Lü
Oncology Research, Vol.26, No.8, pp. 1267-1274, 2018, DOI:10.3727/096504018X15172227703244
Abstract B7-homolog 4 (B7-H4), a member of the B7 family of costimulatory molecules, has been reported to be
upregulated in urothelial cell carcinoma. This study was conducted to explore the biological role of B7-H4
in the aggressiveness of bladder cancer and the associated molecular mechanism. We found that the mRNA
and protein levels of B7-H4 were significantly greater in bladder cancer cell lines than in SV-HUC-1 (normal
human urothelial cells). Overexpression of B7-H4 significantly promoted bladder cancer cell migration and
invasion, whereas knockdown of B7-H4 exerted an opposite effect. However, the growth of bladder cancer
cells More >
Login
Register
