EGOR V. BATOROV1,2,*, ALISA D. INESHINA2, TATIANA A. ARISTOVA3, VERA V. DENISOVA3, SVETLANA A. SIZIKOVA3, DARIA S. BATOROVA3, GALINA Y. USHAKOVA3, EKATERINA Y. SHEVELA1, ELENA R. CHERNYKH1
Oncology Research, Vol.32, No.10, pp. 1575-1587, 2024, DOI:10.32604/or.2024.047893
Abstract Background: Immune checkpoint ligand-receptor interactions appear to be associated with multiple myeloma (MM) progression. Simultaneously, previous studies showed the possibility of PD-1 and TIM-3 expression on T cells upon stimulation with common γ-chain family cytokines in vitro and during homeostatic proliferation. The aim of the present work was to study the impact of homeostatic proliferation on the expansion of certain T cell subsets up-regulating PD-1 and TIM-3 checkpoint molecules. Methods: The expression of CD25, CD122, CD127 common γ-chain cytokine receptors, phosphorylated signal transducer and activator of transcription-5 (pSTAT5) and eomesodermin (EOMES) was comparatively assessed with flow… More >
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