TRINIDAD MONTERO-VILCHEZ^1,2,*, MANUEL SANCHEZ-DIAZ^1,2, CAROLINA MONTERO-VILCHEZ³, ALVARO SIERRA-SANCHEZ², SALVADOR ARIAS-SANTIAGO^1,2,4

BIOCELL, Vol.46, No.11, pp. 2363-2367, 2022, DOI:10.32604/biocell.2022.021399 - 07 July 2022

Abstract Atopic dermatitis (AD) is a chronic cutaneous inflammatory disease caused by an interaction between genetic, immune and epidermal barrier factors. Several treatments can be used to treat this disease but there are patients that do not respond to actual drugs. So, there is a need to develop effective therapies for AD. Mesenchymal stem cells (MSCs) are non-hematopoietic multipotent adult progenitor cells with immunomodulatory power and self-regenerating capacity to repair tissue damage, so they could be a potential effective treatment for AD. MSCs-Conditioned Medium (CM) and MSCs-exosomes are cell-free preparation with molecules secreted by stem cells More >

Shereen A. Baioumy¹, Dina E. Sallam², Shaimaa A. Abdalgeleel³, Shaimaa H. Fouad⁴, Ahmed S. Khedr⁵, Sara I. Taha⁶

European Cytokine Network, Vol.32, No.3, pp. 55-63, 2021, DOI:10.1684/ecn.2021.0470

Abstract Background: Atopic dermatitis (AD) is a common skin disorder accompanied by skin barrier disruption. Patients with AD are commonly affected by food allergy. Objectives: The present case–control study aimed to assess interleukin-17A (IL-17A) serum levels in children with AD and food allergies and to determine whether increased serum levels of this inflammatory cytokine correlate with disease severity. Methods: Healthy control subjects and patients were tested for food allergen reactivity by skin prick test and specific, as well as total, immunoglobulin E (IgE) analysis. IL-17A serum levels were measured by enzyme-linked immunosorbent assay technique. Results: Patients… More >

Abdullah Alyoussef

European Cytokine Network, Vol.26, No.2, pp. 38-45, 2015, DOI:10.1684/ecn.2015.0364

Abstract Purpose: Atopic dermatitis (AD) is a chronically relapsing, pruritic, eczematous skin disorder accompanying allergic inflammation. AD is triggered by oxidative stress and immune imbalance. The effect of oral arjunolic acid (AA) on 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis in mice was investigated. Methods: Repeated epicutaneous application of DNCB to the ear and shaved dorsal skin of mice was performed to induce AD-like symptoms and skin lesions: 250mg/kg AA was given orally for three weeks to assess its anti-pruritic effects. Serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-4, IL-6, IL-10, immunoglobulin (Ig)E and caspase-3 were assessed by More >

Matteo Auriemma¹, Giovina Vianale¹, Paolo Amerio², Marcella Reale¹

European Cytokine Network, Vol.24, No.1, pp. 37-44, 2013, DOI:10.1684/ecn.2013.0333

Abstract Atopic dermatitis (AD) is an inflammatory disorder of the skin characterized by an impaired immune response. Several effector T cell subsets, such as pro-inflammatory cells like Th9, Th17 and Th22 cells, expressing high levels of IL-9, IL-17 and IL-22, together with the anti-inflammatory, immuno-modulating Treg cells constitutively producing IL-10, seem to play a role in this condition. IL-9 and IL-9 receptors are significantly increased in lesional AD skin compared to normal control skin. In addition, some polymorphisms in IL-9 and IL-9r genes have been associated with AD. The role of IL-17 and IL-17-producing T cells… More >

Nasrin Behniafard¹, Mohammad Gharagozlou¹, Elham Farhadi^2,3, Mojdeh Khaledi⁴, Soheila Sotoudeh¹, Behzad Darabi¹, Seid Mohammad Fathi¹, Zahra Gholizadeh Moghaddam¹, Mahdi Mahmoudi⁵, Asghar Aghamohammadi^1,6, Ali Akbar Amirzargar², Nima Rezaei^1,2,6

European Cytokine Network, Vol.23, No.4, pp. 163-165, 2012, DOI:10.1684/ecn.2012.0323

Abstract Tumor necrosis factor-alpha (TNF-α) could be considered as potential biomarkers in atopic dermatitis (AD), while its level could be influenced by cytokine single gene polymorphisms (SNP). This study was performed in 89 pediatric patients with AD and 137 controls to assess polymorphisms of the TNF-α gene at positions -308 and -238, using the polymerase chain reaction and the sequence-specific primers method. The highest positive allelic association that made the patients susceptible to AD was seen for TNF-α -238/G (p<0.001) and TNF-α -308/G (p = 0.003). The GG genotypes at TNF-α -238 and TNF-α -308, were More >