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  • Open Access

    ABSTRACT

    The Role of Shear Stress in Atherosclerotic Plaque Progression, Destabilization and Rupture

    J. J. Wentzel1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 7-8, 2019, DOI:10.32604/mcb.2019.05696

    Abstract The pathophysiology of atherosclerosis is complex and multifactorial, involving systemic risk factors and biomechanical stimuli. Atherosclerotic plaques predominantly form in regions that are exposed to low shear stress of the blood at the vessel wall, whereas regions of moderate and high shear stress are generally protected. For more than 20 years, my research group performs studies to investigate the role of shear stress in atherosclerotic plaque formation and rupture in coronary and carotid arteries of patients and laboratory animals. For that reason, new technology was developed to 3D reconstruct arteries based on fusion of multiple… More >

  • Open Access

    ABSTRACT

    Fluid-Structure Interaction Human Carotid Plaque Progression Simulation Using 3D Meshless Generalized Finite Difference Models Based on Patient-Tracking In Vivo MRI Data

    Dalin Tang1, Chun Yang2, Satya Atluri3

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.18, No.3, pp. 67-68, 2011, DOI:10.3970/icces.2011.018.067

    Abstract Cardiovascular disease is the leading cause of death worldwide. Many victims of the disease died suddenly without prior symptoms. It is a great challenge for clinicians and researchers to develop screening techniques and assessment methodologies to identify those patients for early treatment and prevention of the fatal clinical event. Considerable effort has been devoted investigating mechanisms governing atherosclerotic plaque progression and rupture [Friedman, Bargeron, Deters, Hutchins and Mark (1987); Friedman and Giddens (2005); Giddens, Zarins, Glagov, S. (1993); Ku, Giddens, Zarins and Glagov (1985); Gibson et al. (1993); Liu and Tang (2010); Stone et al.… More >

  • Open Access

    ARTICLE

    Patient-Specific Carotid Plaque Progression Simulation Using 3D Meshless Generalized Finite Difference Models with Fluid-Structure Interactions Based on Serial In Vivo MRI Data

    Chun Yang1,2, Dalin Tang2, Satya Atluri3

    CMES-Computer Modeling in Engineering & Sciences, Vol.72, No.1, pp. 53-78, 2011, DOI:10.3970/cmes.2011.072.053

    Abstract Previously, we introduced a computational procedure based on three-dimensional meshless generalized finite difference (MGFD) method and serial magnetic resonance imaging (MRI) data to quantify patient-specific carotid atherosclerotic plaque growth functions and simulate plaque progression. Structure-only models were used in our previous report. In this paper, fluid-stricture interaction (FSI) was added to improve on prediction accuracy. One participating patient was scanned three times (T1, T2, and T3, at intervals of about 18 months) to obtain plaque progression data. Blood flow was assumed to laminar, Newtonian, viscous and incompressible. The Navier-Stokes equations with arbitrary Lagrangian-Eulerian (ALE) formulation… More >

  • Open Access

    ARTICLE

    Three-Dimensional Carotid Plaque Progression Simulation Using Meshless Generalized Finite Difference Method Based on Multi-Year MRI Patient-Tracking Data

    Chun Yang1,2, Dalin Tang2,3 Satya Atluri4

    CMES-Computer Modeling in Engineering & Sciences, Vol.57, No.1, pp. 51-76, 2010, DOI:10.3970/cmes.2010.057.051

    Abstract Cardiovascular disease (CVD) is becoming the number one cause of death worldwide. Atherosclerotic plaque rupture and progression are closely related to most severe cardiovascular syndromes such as heart attack and stroke. Mechanisms governing plaque rupture and progression are not well understood. A computational procedure based on three-dimensional meshless generalized finite difference (MGFD) method and serial magnetic resonance imaging (MRI) data was introduced to quantify patient-specific carotid atherosclerotic plaque growth functions and simulate plaque progression. Participating patients were scanned three times (T1, T2, and T3, at intervals of about 18 months) to obtain plaque progression data.… More >

  • Open Access

    ARTICLE

    In Vivo/Ex Vivo MRI-Based 3D Non-Newtonian FSI Models for Human Atherosclerotic Plaques Compared with Fluid/Wall-Only Models

    Chun Yang1, Dalin Tang2, Chun Yuan3, Thomas S. Hatsukami4, Jie Zheng5, Pamela K. Woodard5

    CMES-Computer Modeling in Engineering & Sciences, Vol.19, No.3, pp. 233-246, 2007, DOI:10.3970/cmes.2007.019.233

    Abstract It has been recognized that fluid-structure interactions (FSI) play an important role in cardiovascular disease initiation and development. However, in vivo MRI multi-component FSI models for human carotid atherosclerotic plaques with bifurcation and quantitative comparisons of FSI models with fluid-only or structure-only models are currently lacking in the literature. A 3D non-Newtonian multi-component FSI model based on in vivo/ex vivo MRI images for human atherosclerotic plaques was introduced to investigate flow and plaque stress/strain behaviors which may be related to plaque progression and rupture. Both artery wall and plaque components were assumed to be hyperelastic,… More >

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