Yi-Bin Meng, Xin He, Yun-Fei Huang, Qi-Ning Wu, Yong-Cun Zhou, Ding-Jun Hao

Oncology Research, Vol.25, No.7, pp. 1207-1214, 2017, DOI:10.3727/096504017X14886679715637

Abstract It has been determined that long noncoding RNAs (lncRNAs) are identified as a potential regulatory factor in multiple tumors as well as multiple myeloma (MM). However, the role of colorectal neoplasia differentially expressed (CRNDE) in the pathogenesis of MM remains unclear. In this study, we found that the CRNDE expression level, in MM samples and cell lines, is higher than that in the control detected by real-time qPCR, which is also closely related to tumor progression and poor survival in MM patients. Knockdown of CRNDE significantly inhibits the proliferative vitality of MM cells (U266 and… More >

Ming Zhang^*, Change Gao^†, Yi Yang^*, Gaofeng Li^‡, Jian Dong^§, Yiqin Ai^*, Nan Chen^‡, Wenhui Li^*

Oncology Research, Vol.26, No.8, pp. 1245-1255, 2018, DOI:10.3727/096504017X14944585873668

Abstract Long noncoding RNAs (lncRNAs), a new class of functional regulators involved in human tumorigenesis, have been attracting the increasing attention of researchers. The lncRNA colorectal neoplasia differentially expressed (CRNDE) gene, transcribed from chromosome 16 on the strand opposite the adjacent IRX5 gene, was originally found to be increased in CRC and was reported to be abnormally expressed in many cancers. However, its potential role and the molecular mechanism underlying the radioresistant phenotype formation of lung adenocarcinoma (LAD) remain unclear. In our present study, we identified that CRNDE was significantly upregulated in LAD tissue and radioresistant… More >

HYUNHO KIM¹, UIJU CHO², SOOK HEE HONG³, HYUNG SOON PARK¹, IN-HO KIM³, HO JUNG AN¹, BYOUNG YONG SHIM¹, JIN HYOUNG KANG^3,*

Oncology Research, Vol.32, No.6, pp. 1021-1030, 2024, DOI:10.32604/or.2024.048919

Abstract Background: Apolipoprotein B mRNA editing catalytic polypeptide (APOBEC), an endogenous mutator, induces DNA damage and activates the ataxia telangiectasia and Rad3-related (ATR)-checkpoint kinase 1 (Chk1) pathway. Although cisplatin-based therapy is the mainstay for muscle-invasive bladder cancer (MIBC), it has a poor survival rate. Therefore, this study aimed to evaluate the efficacy of an ATR inhibitor combined with cisplatin in the treatment of APOBEC catalytic subunit 3B (APOBEC3B) expressing MIBC. Methods: Immunohistochemical staining was performed to analyze an association between APOBEC3B and ATR in patients with MIBC. The APOBEC3B expression in MIBC cell lines was assessed… More >

Puja S. Prasad¹, Adepu Sree Lakshmi¹, Sandeep Kautish², Simar Preet Singh³, Rajesh Kumar Shrivastava³, Abdulaziz S. Almazyad⁴, Hossam M. Zawbaa⁵, Ali Wagdy Mohamed^6,7,*

CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.1, pp. 725-739, 2024, DOI:10.32604/cmes.2023.030640

Abstract Pupil dynamics are the important characteristics of face spoofing detection. The face recognition system is one of the most used biometrics for authenticating individual identity. The main threats to the facial recognition system are different types of presentation attacks like print attacks, 3D mask attacks, replay attacks, etc. The proposed model uses pupil characteristics for liveness detection during the authentication process. The pupillary light reflex is an involuntary reaction controlling the pupil’s diameter at different light intensities. The proposed framework consists of two-phase methodologies. In the first phase, the pupil’s diameter is calculated by applying… More >

YIFAN LI^1,2, JING ZHANG¹, YITAO FAN¹, HANDAN XIAO¹, KEXIN KANG¹, YALI ZHOU¹, ZHIWEN ZHANG^3,*, YUMIN LI¹, MUZHOU TENG^1,*

BIOCELL, Vol.47, No.8, pp. 1783-1791, 2023, DOI:10.32604/biocell.2023.028056

Abstract Background: ((1-triphenylaminebenzo[c][1,2,5] thiadiazole-4-yl) styryl)-1-methylpyridin methylpyridin-1-ium iodide salt (TBZPy) is a novel photosensitizer that displays excellent photodynamic properties. However, There are few reports on the mechanism of action of the TBZPy photodynamic. Previous studies revealed that photodynamic therapy (PDT) could induce endoplasmic reticulum stress by acting on the endoplasmic reticulum. Therefore, in this study, we investigated the effects of endoplasmic reticulum stress induced by TBZPy-PDT in treating High-risk human papillomavirus (HR-HPV) infection and their underlying mechanisms. Methods: The human cervical cancer cell line HeLa (containing whole genome of HR-HPV18) was treated with TBZPy-PDT. Cell migration, invasion,… More > Graphic Abstract

ZICHEN SHAO^1,2,#, CHUNG-YI CHEN^3,#, XUZHOU CHEN¹, HANWU CHEN¹, MENGQIAO SU^1,2, HUI SUN^1,2, YIDAN LI^1,2, BINGHUA TU¹, ZITONG WANG¹, CHI-MING LIU^1,*

BIOCELL, Vol.47, No.6, pp. 1389-1396, 2023, DOI:10.32604/biocell.2023.028222

Abstract Background: Benign prostatic hyperplasia (BPH) is a common condition in middle-aged and elderly men. Enlargement of the prostate causes lower urinary tract symptoms. Capsaicin is a phytochemical extracted from chili peppers and exerts many pharmacological actions, such as anti-tumor and anti-inflammatory effects. Methods: Our study investigated the effect of capsaicin in vitro and in a mouse model in vivo. A prostatic stromal myofibroblast cell line (WPMY-1) was co-incubated with testosterone (1 µM) and different concentrations of capsaicin (10–100 µM) for 24 and 48 h. Capsaicin (10–100 µM) significantly inhibited testosterone-treated WPMY-1 cell growth at 48 h by MTT… More >

Mohsen Sharifpur^1,2, Mohamed Salem³, Yonis M Buswig⁴, Habib Forootan Fard⁵, Jaroon Rungamornrat^6,*

CMC-Computers, Materials & Continua, Vol.74, No.3, pp. 5679-5690, 2023, DOI:10.32604/cmc.2023.034726

Abstract Residential sector is one of the energy-consuming districts of countries that causes CO₂ emission in large extent. In this regard, this sector must be considered in energy policy making related to the reduction of emission of CO₂ and other greenhouse gases. In the present work, CO₂ emission related to the residential sector of three countries, including Indonesia, Thailand, and Vietnam in Southeast Asia, are discussed and modeled by employing Group Method of Data Handling (GMDH) and Multilayer Perceptron (MLP) neural networks as powerful intelligent methods. Prior to modeling, data related to the energy consumption of these countries… More >

Pavitra Vasudevan¹, R. Faerie Mattins¹, S. Srivarshan¹, Ashvath Narayanan¹, Gayatri Wadhwani¹, R. Parvathi¹, R. Maheswari^2,*

CMC-Computers, Materials & Continua, Vol.74, No.3, pp. 6039-6063, 2023, DOI:10.32604/cmc.2023.032331

Abstract Gait refers to a person’s particular movements and stance while moving around. Although each person’s gait is unique and made up of a variety of tiny limb orientations and body positions, they all have common characteristics that help to define normalcy. Swiftly identifying such characteristics that are difficult to spot by the naked eye, can help in monitoring the elderly who require constant care and support. Analyzing silhouettes is the easiest way to assess and make any necessary adjustments for a smooth gait. It also becomes an important aspect of decision-making while analyzing and monitoring… More >

Shaopeng Li, Peng Wang, Jun Qiu, Yiju Xie, Dawei Yin, Kexue Deng^*

Oncologie, Vol.24, No.3, pp. 527-538, 2022, DOI:10.32604/oncologie.2022.022815

Abstract Background: To compare the differential diagnostic value of iterative decomposition of water and fat with the echo asymmetrical and least-squares estimation quantitation sequence (IDEAL-IQ) with that of intravoxel incoherent motion diffusion-weighted imaging (IVIM DWI) in differentiating between alpha fetoprotein (AFP)-negative hepatocellular carcinoma (HCC) and focal nodular hyperplasia (FNH). Materials and Methods: A total of 28 AFP-negative HCC cases and 15 FNH cases were scanned using the IDEAL-IQ and IVIM-DWI magnetic resonance imaging (MRI) protocols. Two radiologists independently assessed the fat fraction (FF) and the iron level surrogate (R2*) derived from the IDEAL-IQ images and the apparent diffusion… More >

Mahesh B. Shelke¹, Jeong Gon Lee^2,*, Sovan Samanta³, Sachin N. Deshmukh¹, G. Bhalke Daulappa⁴, Rahul B. Mannade⁵, Arun Kumar Sivaraman⁶

Computer Systems Science and Engineering, Vol.44, No.3, pp. 2457-2468, 2023, DOI:10.32604/csse.2023.027979

Abstract In today’s digital world, millions of individuals are linked to one another via the Internet and social media. This opens up new avenues for information exchange with others. Sentiment analysis (SA) has gotten a lot of attention during the last decade. We analyse the challenges of Sentiment Analysis (SA) in one of the Asian regional languages known as Marathi in this study by providing a benchmark setup in which we first produced an annotated dataset composed of Marathi text acquired from microblogging websites such as Twitter. We also choose domain experts to manually annotate Marathi More >