Yao Shi*, Xiaoke Sun†, Xiafen He‡
Oncology Research, Vol.25, No.1, pp. 11-18, 2017, DOI:10.3727/096504016X14685034103833
Abstract Aristaless-like homeobox-4 (ALX4), a member of the Aristaless-like homeobox family, has been found to be
involved in tumor cell proliferation, migration, and invasion. However, the role of ALX4 in hepatocellular
carcinoma (HCC) remains largely unclear. Therefore, in this study we investigated the effects of ALX4 on
HCC. The study results indicated that the expression of ALX4 was downregulated in HCC tissues and cell
lines. Furthermore, we demonstrated that overexpression of ALX4 inhibited the proliferation, invasion, and
epithelial–mesenchymal transition (EMT) in HCC cells. We also found that ALX4 had an inhibitory effect on
the sonic hedgehog More >
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