SAYEQUA DANDOTI*
BIOCELL, Vol.45, No.4, pp. 863-884, 2021, DOI:10.32604/biocell.2021.013993
- 22 April 2021
Abstract Inactivation of apoptosis is the prime phenomenon in cancer development and cancer treatments. Mutations in
the apoptotic pathway not only exert resistance to apoptosis and provide a survival advantage to cancer cells but also
confer resistance to cancer therapies. Escaping apoptosis is the “hallmark” of cancer cells. Cancer cells can withstand
many apoptotic stimuli, such as DNA damage, unfavorable environments, and cytotoxic therapies. Substantial
research has been carried out and is in good progress on the various mechanisms adopted by cancer cells to evade
apoptosis. This article reviews the apoptosis escape mechanisms by cancer cells, More >
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