Fuat USLUSOY1, Mustafa NAZIROĞLU2,3,*
BIOCELL, Vol.43, No.4, pp. 271-283, 2019, DOI:10.32604/biocell.2019.08333
Abstract The wound is induced by several mechanical and metabolic factors. In the etiology of the wound recovery,
excessive oxidative stress, calcium ion (Ca2+) influx, and apoptosis have important roles. Ca2+-permeable TRPM2 channel is activated by oxidative stress. Protective roles of Hypericum perforatum extract (HP) on the mechanical nerve injury-induced apoptosis and oxidative toxicity through regulation of TRPM2 in the experimental animals were
recently reported. The potential protective roles in HP treatment were evaluated on the TRPM2-mediated cellular
oxidative toxicity in the renal epithelium (MPK) cells. The cells were divided into three groups as control, wound,
and wound… More >
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