Angelica Perna*†, Angela Lucariello*†, Carmine Sellitto*, Iolanda Agliata†, Maria Aurora Carleo‡, Vincenzo Sangiovanni‡, Vincenzo Esposito§, Germano Guerra†,
Luigi Cobellis¶, Antonio De Luca*
Oncology Research, Vol.25, No.9, pp. 1617-1624, 2017, DOI:10.3727/096504017X14905635363102
Abstract Antiretroviral drugs used for the treatment of human immunodeficiency virus (HIV) have proven to be effective even against cancer. Drawing from this background, the aim of our research project was to evaluate the
effects of anti-HIV drugs that belong to the nucleoside and nucleotide reverse transcriptase inhibitor [NRTI;
abacavir (ABC) and tenofovir (TDF)], nonnucleoside reverse transcriptase inhibitor [NNRTI; efavirenz (EFV)
and etravirine (ETR)], and protease inhibitor [PI; darunavir (DRV)] categories on ovarian adenocarcinoma cell
line SKOV-3. Using FACS analysis, we observed that treatment with NRTIs and NNRTIs showed a block in
the G0/G1 phase. In particular,… More >
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