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  • Open Access

    REVIEW

    Impact of nanoparticles on immune cells and their potential applications in cancer immunotherapy

    JYOTHI B. NAIR1,2, ANU MARY JOSEPH3, SANOOP P.4, MANU M. JOSEPH5,*

    BIOCELL, Vol.48, No.11, pp. 1579-1602, 2024, DOI:10.32604/biocell.2024.054879 - 07 November 2024

    Abstract Nanoparticles represent a heterogeneous collection of materials, whether natural or synthetic, with dimensions aligning in the nanoscale. Because of their intense manifestation with the immune system, they can be harvested for numerous bio-medical and biotechnological advancements mainly in cancer treatment. This review article aims to scrutinize various types of nanoparticles that interact differently with immune cells like macrophages, dendritic cells, T lymphocytes, and natural killer (NK) cells. It also underscores the importance of knowing how nanoparticles influence immune cell functions, such as the production of cytokines and the presentation of antigens which are crucial for… More >

  • Open Access

    ARTICLE

    The role of host immune cells and Borrelia burgdorferi antigens in the etiology of Lyme disease

    Dennis Verhaegh, Leo A. B. Joosten, Marije Oosting

    European Cytokine Network, Vol.28, No.2, pp. 70-84, 2017, DOI:10.1684/ecn.2017.0396

    Abstract Lyme disease is a zoonosis caused by infection with bacteria belonging to the Borrelia burgdorferi species after the bite of an infected tick. Even though an infection by this bacterium can be effectively treated with antibiotics, when the infection stays unnoticed B. burgdorferi can persist and chronic post-treatment Lyme disease syndrome is able to develop. Although a cellular and humoral response is observed after an infection with theBorrelia bacteria, these pathogens are still capable to stay alive. Several immune evasive mechanisms have been revealed and explained and much work has been put into the understanding of the… More >

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