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    ARTICLE

    Prenatal exposure to the fluoride containing psychiatric drug fluoxetine and anti-oxidative alterations in the neonatal rat brain

    Ramesa Shafi BHAT1, Amina El GEZEERY2, Abir Ben BACHAN1, Mona Awad ALONAZI1, Leena Saleh ALSUHAIBANI1, Afaf El-ANSARY3,4

    BIOCELL, Vol.43, No.2, pp. 65-71, 2019, DOI:10.32604/biocell.2019.07012

    Abstract Fluoride is a key ingredient of many psychiatric drugs like fluoxetine (Prozac®, Fluoxetine®). Pregnant women frequently use this drug as they suffer from depression and anxiety disorders during this period. Fluoxetine is able to reach the fetus through the placenta and passes to the newborn through milk. In the present study, female Wistar rats were treated with 5, 10, and 20 mg/L fluoxetine (containing 94% fluorides) from pregnancy day 10 to day 20. After delivery, the levels of the enzymatic antioxidants in the brain of their offspring at postnatal day 2 were measured. The results More >

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