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Search Results (20)
  • Open Access

    ARTICLE

    Valtrate exerts anticancer effects on gastric cancer AGS cells by regulating reactive oxygen species-mediated signaling pathways

    JINGLONG CAO1,#, SHUMEI LI2,#, TONG ZHANG1,#, JIAN LIU1, WENSHUANG HOU1, ANQI WANG1, CHANG WANG3,4,*, CHENGHAO JIN1,3,5,*

    BIOCELL, Vol.48, No.2, pp. 313-325, 2024, DOI:10.32604/biocell.2023.043474

    Abstract Background: Valtrate (Val) was extracted from the Valeriana jatamansi Jones plant, had good antitumor activity. However, its precise molecular mechanism in cancer cells was still unclear. This study investigated the effect of Val on gastric cancer (GC) cells and its potential molecular mechanism. Methods: Cell viability was examined by CCK-8 assay. Cell cycle, apoptosis, and Reactive oxygen species (ROS) level were analyzed by flow cytometry. The migration effect of Val on AGS cells was analyzed by transwell and wound-healing assay. The expression levels of proteins were analyzed by western blot. Results: The cell viability assay results demonstrated that Val significantly… More > Graphic Abstract

    Valtrate exerts anticancer effects on gastric cancer AGS cells by regulating reactive oxygen species-mediated signaling pathways

  • Open Access

    MiR-19a-3p/PTEN axis regulates the anticancer effect of circHIAT1 in breast cancer in vitro

    CHAO NIU1,#, RUOFEI SUN1,#, XIAOGANG LI2, BO LI2, XIAODONG HE1,*

    BIOCELL, Vol.47, No.10, pp. 2301-2312, 2023, DOI:10.32604/biocell.2023.029935

    Abstract Objective: Breast cancer is a major cancer threatening the health of women globally. To elucidate the effect of the circHIAT1/miR-19a-3p/phosphatase and tensin homolog (PTEN) axis on regulating the malignant phenotype of breast cancer cells. Methods: The mRNA expression pattern of circHIAT1, miR-19a-3p, and PTEN was checked by real-time quantitative polymerase chain reaction. Then, the knockdown assay was carried out to explore the effect of circHIAT1 and miR-19a-3p on breast cancer. The relative cell experiments, including MTT assay, scratch assay, transwell invasion assay, and flow cytometry analysis, were conducted to verify the influence of circHIAT1 and miR-19a-3p on breast cancer cells.… More >

  • Open Access

    ARTICLE

    Deoxynortryptoquivaline: A unique antiprostate cancer agent

    YOHKO YAMAZAKI1,*, MANABU KAWADA2, ISAO MOMOSE1

    Oncology Research, Vol.31, No.6, pp. 845-853, 2023, DOI:10.32604/or.2023.030266

    Abstract The androgen receptor (AR) is a critical target in all the clinical stages of prostate cancer. To identify a new AR inhibitor, we constructed a new screening system using the androgen-dependent growth of prostate cancer cell lines as a screening indicator. We screened 50,000 culture broths of microorganisms using this screening system and found that the fermentation broth produced by a fungus inhibited androgen-dependent growth of human prostate cancer LNCaP cells without cytotoxicity. Purification of this culture medium was performed, and this resulted in deoxynortryptoquivaline (DNT) being identified as a novel inhibitor of AR function. DNT showed potent inhibition of… More > Graphic Abstract

    Deoxynortryptoquivaline: A unique antiprostate cancer agent

  • Open Access

    ARTICLE

    Identification of a dihydroorotate dehydrogenase inhibitor that inhibits cancer cell growth by proteomic profiling

    MAKOTO KAWATANI1,2,*, HARUMI AONO2, SAYOKO HIRANUMA3, TAKESHI SHIMIZU3, MAKOTO MUROI1,2, TOSHIHIKO NOGAWA4, TOMOKAZU OHISHI5, SHUN-ICHI OHBA5, MANABU KAWADA5, KANAMI YAMAZAKI6, SHINGO DAN6, NAOSHI DOHMAE1, HIROYUKI OSADA2,7,*

    Oncology Research, Vol.31, No.6, pp. 833-844, 2023, DOI:10.32604/or.2023.030241

    Abstract Dihydroorotate dehydrogenase (DHODH) is a central enzyme of the de novo pyrimidine biosynthesis pathway and is a promising drug target for the treatment of cancer and autoimmune diseases. This study presents the identification of a potent DHODH inhibitor by proteomic profiling. Cell-based screening revealed that NPD723, which is reduced to H-006 in cells, strongly induces myeloid differentiation and inhibits cell growth in HL-60 cells. H-006 also suppressed the growth of various cancer cells. Proteomic profiling of NPD723-treated cells in ChemProteoBase showed that NPD723 was clustered with DHODH inhibitors. H-006 potently inhibited human DHODH activity in vitro, whereas NPD723 was approximately… More >

  • Open Access

    REVIEW

    Synthesis of Metallic Nanoparticles Based on Green Chemistry and Their Medical Biochemical Applications: Synthesis of Metallic Nanoparticles

    Kakudji Kisimba1, Anand Krishnan2,*, Mbuso Faya1, Kahumba Byanga3, Kabange Kasumbwe4, Kaliyapillai Vijayakumar5, Ram Prasad6,*

    Journal of Renewable Materials, Vol.11, No.6, pp. 2575-2591, 2023, DOI:10.32604/jrm.2023.026159

    Abstract Nanoparticles have distinct properties that make them potentially valuable in a variety of industries. As a result, emerging approaches for the manufacture of nanoparticles are gaining a lot of scientific interest. The biological pathway of nanoparticle synthesis has been suggested as an effective, affordable, and environmentally safe method. Synthesis of nanoparticles through physical and chemical processes uses unsafe materials, expensive equipment and adversely affects the environment. As a result, in order to support the increased utilization of nanoparticles across many sectors, nanotechnology research activities have shifted toward environmentally safe and cost-effective techniques that outperform chemical and/or biological procedures. The use… More > Graphic Abstract

    Synthesis of Metallic Nanoparticles Based on Green Chemistry and Their Medical Biochemical Applications: Synthesis of Metallic Nanoparticles

  • Open Access

    REVIEW

    A comprehensive analysis of the role of molecular docking in the development of anticancer agents against the cell cycle CDK enzyme

    PRIYANKA SOLANKI1, NISARG RANA1, PRAKASH C. JHA2, ANU MANHAS1,*

    BIOCELL, Vol.47, No.4, pp. 707-729, 2023, DOI:10.32604/biocell.2023.026615

    Abstract Cancer is considered one of the most lethal diseases responsible for causing deaths worldwide. Although there have been many breakthroughs in anticancer development, cancer remains the major cause of death globally. In this regard, targeting cancer-causing enzymes is one of the efficient therapeutic strategies. Biological functions like cell cycle, transcription, metabolism, apoptosis, and other depend primarily on cyclin-dependent kinases (CDKs). These enzymes help in the replication of DNA in the normal cell cycle process, and deregulation in the functioning of any CDK can cause abnormal cell growth, which leads to cancer. This review is focused on anticancer drug discovery against… More >

  • Open Access

    ARTICLE

    Insilico Anticancer Peptide Prediction from Curcuma longa

    Sunil Kumar Suryawanshi1, Usha Chouhan2, Jyoti Kant Choudhari2,*

    Molecular & Cellular Biomechanics, Vol.19, No.4, pp. 191-208, 2022, DOI:10.32604/mcb.2022.023911

    Abstract Cancer is the second biggest cause of death globally, and the use of therapeutic peptides to specifically target and destroy cancer cells has gotten much interest. Cancer peptides or vaccinations are utilized to treat cancer nowadays, apart from chemotherapy, which has significant discomfort, side effects and costly. It is time demanding to identify and predict potential anticancer peptides using computational biology approaches. Thus, 3-D molecular modeling is being used to find possible ACP candidates. In this research, Curcuma longa has predicted peptide sequences were docked on breast cancer receptors and used a molecular docking technique to assess the anticipated peptides’… More >

  • Open Access

    ARTICLE

    Schisandrin B exerts anticancer effects on human gastric cancer cells through ROS-mediated MAPK, STAT3, and NF-κB pathways

    TIANZHU LI1,#, YU ZHANG2,#, TONG ZHANG2,#, YANNAN LI2, HUI XUE2, JINGLONG CAO2, WENSHUANG HOU2, YINGHUA LUO3,*, CHENGHAO JIN2,4,*,

    BIOCELL, Vol.47, No.1, pp. 195-204, 2023, DOI:10.32604/biocell.2023.025593

    Abstract Schisandrin B (Sch B) is a monomer with anti-cancer and anti-inflammatory effects, which are isolated from the plant Schisandra chinensis (Turcz) Baillon. We investigated the anti-gastric cancer (GC) effects of Sch B and its underlying molecular mechanisms. The Cell Counting Kit-8 assay was used to determine the effects of Sch B on the viability of GC and normal cell lines. Hoechst/propidium iodide staining and flow cytometry were used to assess the apoptosis induction of Sch B. Western blotting was used to evaluate the effects of Sch B on downstream apoptotic proteins. The DCFH-DA fluorescent probe was used to assess the… More >

  • Open Access

    ARTICLE

    Long noncoding RNA LINC01124 activates hepatocellular carcinoma cell proliferation, migration, and invasion by absorbing microRNA-1247-5p and overexpressing FOXO3

    LEI SUN1,2, YUE ZHANG3, YUQIN YAO4, HONGLIN DU3, YUEHUA ZHANG1, AIPING FANG1,2,*

    Oncology Research, Vol.29, No.3, pp. 175-187, 2021, DOI:10.32604/or.2022.03550

    Abstract Long intergenic non-protein coding RNA 1124 (LINC01124) has been identified as an important regulator of non-small-cell lung cancer. However, the expression and detailed role of LINC01124 in hepatocellular carcinoma (HCC) remain unestablished to date. Therefore, this study aimed to elucidate the role of LINC01124 in the aggressiveness of HCC cells and identify the underlying regulatory mechanism. Quantitative reverse transcriptase-polymerase chain reaction was performed to measure the expression of LINC01124 in HCC. Cell Counting Kit-8 assay, Transwell cell migration and invasion assays, and a xenograft tumor model were used to investigate the function of LINC01124 in HCC cells, and bioinformatics analysis,… More >

  • Open Access

    ARTICLE

    Anticancer efficacy of 3-(4-isopropyl) benzylidene-8-ethoxy, 6-methyl, chroman-4-one (SBL-060), a novel, dual, estrogen receptor-Akt kinase inhibitor in acute myeloid leukemia cells

    MESFER AL SHAHRANI1,2,*, PRASANNA RAJAGOPALAN1,2, MOHAMMAD ABOHASSAN1, MOHAMMAD ALSHAHRANI1, YASSER ALRAEY1, REEM M. GAHTANI1, SURESH RADHAKRISHNAN3, KHLOOD DAGREERY4

    Oncology Research, Vol.29, No.3, pp. 149-157, 2021, DOI:10.32604/or.2022.03539

    Abstract Estrogen receptor (ER) α is expressed in a subset of patient-derived acute myeloid leukemia (AML) cells, whereas Akt is predominantly expressed in most types of AML. Targeting AML with dual inhibitors is a novel approach to combat the disease. Herein, we examined a novel small molecule, 3-(4-isopropyl) benzylidene-8-ethoxy,6- methyl, chroman-4-one (SBL-060), capable of targeting AML cells by inhibiting ERα and Akt kinase. The chemical properties of SBL-060 were identified by proton nuclear magnetic resonance (1 H-NMR), 13C-NMR, and mass spectroscopy. In silico docking was performed using an automated protocol with AutoDock-VINA. THP-1 and HL-60 cell lines were differentiated using phorbol… More >

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