Zeng Cheng Zou*1, Min Dai*1, Zeng Yin Huang†, Yi Lu‡, He Ping Xie*, Yi Fang Li§, Yue Li*, Ying Tan¶, Feng Lin Wang*
Oncology Research, Vol.26, No.9, pp. 1391-1399, 2018, DOI:10.3727/096504018X15178798885361
Abstract The direct roles of miR-139-3p on hepatocellular carcinoma (HCC) cell growth and metastasis remain poorly
understood. We attempted to demonstrate the regulatory role of miR-139-3p in HCC progression and its underlying mechanisms. Here we showed that miR-139-3p expression was significantly reduced in the HCC tissues
compared to paratumor tissues. Exogenous overexpression of miR-139-3p inhibited the migration and invasion of HCC cells, whereas downregulation of miR-139-3p was able to induce HCC HepG2 and SNU-449
cell migration and invasion. In addition, miR-139-3p inhibited HCC growth and lung metastasis in an in vivo
mouse model, which is mainly More >
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