FEI CHENG1,#, YIQIAN DING2,#, QING XU3, WEI ZHANG3, YULAN ZHEN4, JING LIU5, SHICHENG LI1, CHANG TU1, GUOHUA LAI1, JUN LAN1,*, JINGFU CHEN1,*
BIOCELL, Vol.46, No.4, pp. 1053-1066, 2022, DOI:10.32604/biocell.2021.012901
- 15 December 2021
Abstract Previous reports have suggested that Ang-(1-7) may have a protective effect in endothelial cells against high
glucose (HG)-induced cell injury thanks to a modulatory mechanism in the NF-κB signaling pathway. In this study,
we have examined whether NF-κB-IL-1β and Heme oxygenase-1 (HO-1) pathways contribute to the protection of
Ang-(1-7) against hyperglycemia-induced inflammation and oxidative stress in human umbilical vein endothelial cells
(HUVECs). Our results indicate that time-varying exposures of HUVECs, from 1 h to 24 h, to high glucose
concentrations result in an increased expression of phosphorylated (p)-p65 and HO-1 in a time-dependent manner.
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