ALICIA VIVIANA LAPIERRE, MARIA ELENA ARCE, JOSÉ RAUL LOPEZ, GLADYS MARÍA CIUFFO.
BIOCELL, Vol.30, No.3, pp. 447-455, 2006, DOI:10.32604/biocell.2006.30.447
Abstract Essential hypertension is considered a multifactorial trait resulting from a combination of environmental and genetic factors. The angiotensin II type 1 receptor mediates the vasoconstrictor and growthpromoting effects of Ang II. The A1166C polymorphism of the AT1 receptor gene may be associated with cardiovascular phenotypes, such as high arterial blood pressure, aortic stiffness, and increased cardiovascular risk. We investigated the association between this A1166C polymorphism and hypertension in hypertense and normotense subjects from San Luis (Argentina) by mismatch PCR-RFLP analysis. Hypertense patients exhibited significant increases in lipid related values and body mass index. The frequency of occurrence… More >
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