Li-Kun Yang*1, Jie Zhu*1, Yu-Hua Chen†1, Dong-Liang Wang‡, Hua Li§, Liang-Jun Zhang§, Jing-Ru Zhou‡, Wei Liu†
Oncology Research, Vol.25, No.8, pp. 1349-1355, 2017
Abstract Angiopoietin-like protein 2 (ANGPTL2), a member of the glycoprotein family, is mainly secreted by adipose tissues under normal conditions. Recently, ANGPTL2 has been found to be upregulated in some types
of cancers and is considered to be a tumor promoter. However, the functional significance of ANGPTL2 in
glioma has not yet been elucidated. In this study, we investigated the specific role of ANGPTL2 in glioma. The
results showed that ANGPTL2 was highly expressed in glioma tissues and cell lines. Knockdown of ANGPTL2
reduced the proliferative and invasive abilities of glioma cells. Moreover, the tumorigenesis assay More >
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