Jean-Baptiste Lattouf¹, Jenny J. Ko², Margot K. Davis³, Christian Constance⁴, Geoffrey T. Gotto⁵

Canadian Journal of Urology, Vol.31, No.5, pp. 11977-11985, 2024

Abstract Introduction: Niraparib, a PARP1/2 inhibitor, is newly approved in combination with abiraterone acetate (AA) plus prednisone or prednisolone (niraparib/AA+P) for the treatment of adult patients with BRCA-mutated, treatment-naïve metastatic castration resistant prostate cancer (mCRPC). Detailed guidance beyond the prescribing information may be helpful in managing the side effect profile and dosing practicalities of this combination therapy.
Materials and methods: A panel of specialists convened to design management algorithms for four common niraparib/ AA+P treatment-related adverse events (AEs) in mCRPC; anemia, thrombocytopenia, hypertension, and nausea. The algorithms build on Health Canada-approved prescribing information to highlight practical considerations related… More >

Abdullah A. Alharbi¹, Ahmad Y. Alqassim^1,*, Mohammed A. Muaddi¹, Najat H. Aldubayyan¹, Rana I. Abuhadi¹, Futon A. Akoor¹, Sarah J. Mobarki¹, Imtenan A. Oberi¹, Ghaidaa H. Alharbi¹, Yara Ajeebi¹, Adnan M. Alkhayat², Hafiz Malhan³, Mohammed Bakkar⁴, Anwar M. Makeen¹

International Journal of Mental Health Promotion, Vol.26, No.5, pp. 351-359, 2024, DOI:10.32604/ijmhp.2024.047219 - 30 May 2024

Abstract Sickle Cell Anemia (SCA) is a prevalent genetic condition in Saudi Arabia, particularly in the Jazan region. The study’s purpose was to assess the prevalence of de-pression among individuals with SCA in this area and to identify the factors associated with this condition. The study involved 391 adult participants, all patients in the hematology center of Prince Mohammed bin Nasser Hospital (PMNH). Data was collected through an anonymous interview questionnaire–the Arabic version of the Patient Health Questionnaire-9 (PHQ-9)–between March–May 2022. The questionnaire covered socio-demographic information and variables related to the participant’s SCA history, such as… More >

JIUCHUN GUO¹, JIE PAN^2,*, QIANQIAN GUO²

BIOCELL, Vol.46, No.2, pp. 505-510, 2022, DOI:10.32604/biocell.2021.015785 - 20 October 2021

Abstract The excessive energy of light, especially the invisible rays with lower wavelength, is basically absorbed by retinal pigment epithelium (RPE) and usually causes DNA damage. The molecular mechanism behind DNA damage repair response to this frequent stress in RPE is not clearly understood. In this study, we determined that the Fanconi anemia (FA) pathway was activated in human RPE ARPE-19 cells after ultraviolet (UV) B and C treatment. Moreover, immunoprecipitation (IP) of FANCD2 indicated that denticleless E3 ubiquitin protein ligase homolog (DTL) closely interacted with FANCD2. Knockdown of DTL weakened the activity of the FA More >

Takashi Saito^*†, Atsuo Okamura^‡, Junichiro Inoue^†, Daisuke Makiura^†, Hisayo Doi^§, Kimikazu Yakushijin^¶, Hiroshi Matsuoka^¶, Yoshitada Sakai^†#, Rei Ono^*

Oncology Research, Vol.27, No.4, pp. 469-474, 2019, DOI:10.3727/096504018X15267574931782

Abstract Chemotherapy-induced peripheral neuropathy (CIPN) frequently occurs in lymphoma patients receiving R-CHOP, a drug combination therapy. Although severe CIPN may lead to reduction and/or discontinuation of the medication, predictive factors of CIPN have not been investigated sufficiently to date. We performed a retrospective exploratory research to determine associations between prevalence of severe CIPN and sociodemographic data, health characteristics, and medical conditions such as anemia at initial diagnosis. Forty patients (indolent lymphoma, n=9; diffuse large B-cell lymphoma; n=31) received R-CHOP therapy from September 2009 to July 2014. The median age of patients was 58 years (range=27–76 years). Statistical More >

Bijan Keikhaei¹, Ali Reza Mohseni², Reza Norouzirad³, Mastaneh Alinejadi⁴, Somayeh Ghanbari¹, Fariba Shiravi¹, Ghasem Solgi⁵

European Cytokine Network, Vol.24, No.1, pp. 45-52, 2013, DOI:10.1684/ecn.2013.0328

Abstract Objective: This study aimed to evaluate serum levels of pro-inflammatory cytokines and TGF-β in sickle cell disease (SCD) patients, and to compare the results during vaso-occlusive crisis (VOC) or steady state (StSt) conditions. Methods: 54 SCD patients (37HbSS and 17Sβ⁺Thal) were enrolled in the study and evaluated in two groups as follows; group A consisted of 39 VOC patients and group B comprised 15 StSt patients. Nineteen healthy volunteers were included as controls. Circulating levels of IL-1, IL-6, IL-8, IL-17,TNF-α and TGF-β were measured using ELISA. Results: Patients in VOC showed higher mean levels of all… More >

Richard Choo^1,2, Sarat Chander^1,3, Cyril Danjoux¹, Gerard Morton¹, Andrew Pearce¹, Gerrit Deboer¹, Ewa Szumacher¹, Andrew Loblaw¹, Patrick Cheung¹, Tony Woo¹

Canadian Journal of Urology, Vol.12, No.1, pp. 2547-2552, 2005

Abstract Purpose: To examine the change of hemoglobin in relation to testosterone level in non-metastatic prostate cancer patients receiving 2-year androgen suppression.
Methods and materials: A cohort of 72 patients, as participants of a phase II study, were treated with adjuvant radiotherapy plus 2-year androgen suppression after surgery to reduce the risk of relapse. Patients had laboratory tests including hemoglobin (Hb) and testosterone, and a quality of life questionnaire at regular intervals during the androgen suppression and post-androgen suppression period. The pattern of the change in Hb was evaluated in relation to testosterone level. The clinical significance of… More >