SIDDAVARAM NAGINI1, PRATHAP REDDY KALLAMADI2, KRANTHI KIRAN KISHORE TANAGALA3, GEEREDDY BHANUPRAKASH REDDY2,*
Oncology Research, Vol.32, No.8, pp. 1287-1308, 2024, DOI:10.32604/or.2024.049918
Abstract Aldo-keto reductases (AKRs) are a superfamily of enzymes that play crucial roles in various cellular processes, including the metabolism of xenobiotics, steroids, and carbohydrates. A growing body of evidence has unveiled the involvement of AKRs in the development and progression of various cancers. AKRs are aberrantly expressed in a wide range of malignant tumors. Dysregulated expression of AKRs enables the acquisition of hallmark traits of cancer by activating oncogenic signaling pathways and contributing to chemoresistance. AKRs have emerged as promising oncotherapeutic targets given their pivotal role in cancer development and progression. Inhibition of aldose reductase… More >
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