Maximiliano GIRAUD-BILLOUD1, 2*, Fernando EZQUER2, Javiera BAHAMONDE2, Marcelo EZQUER2
BIOCELL, Vol.41, No.1, pp. 1-12, 2017, DOI:10.32604/biocell.2017.41.001
Abstract A decrease in the tubular expression of albumin endocytic transporters megalin and cubilin has been
associated with diabetic nephropathy, but there are no comprehensive studies to date relating early tubulointerstitial
injury and the effect of the disease on both transporters in type 1 diabetes mellitus (T1DM). We used eight-weekold male C57BL/6 mice divided into two groups; one of them received the vehicle (control group), while the other
received the vehicle + 200 mg/kg streptozotocin (T1DM). Ten weeks after the injection, we evaluated plasma insulin,
enzymuria, urinary vitamin D-binding protein (VDBP), tubulointerstitial fibrosis and proximal… More >
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