Mingzhi Luo1, Kai Ni1, Peili Yu1, Yang Jin2, Lei Liu1, Jingjing Li1, Yan Pan1, Linhong Deng1,*
Molecular & Cellular Biomechanics, Vol.16, No.2, pp. 141-151, 2019, DOI:10.32604/mcb.2019.06756
Abstract Airway hyperresponsiveness (AHR) is the cardinal character of asthma, which involves the biomechanical properties such as cell stiffness and traction force of airway smooth muscle cells (ASMCs). Therefore, these biomechanical properties comprise logical targets of therapy. β2-adrenergic agonist is currently the mainstream drug to target ASMCs in clinical practice for treating asthma. However, this drug is known for side effects such as desensitization and non-responsiveness in some patients. Therefore, it is desirable to search for new drug agents to be alternative of β2-adrenergic agonist. In this context, sanguinarine, a natural product derived from plants such… More >
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