YONGLI ZHANG1,#, YIZHAN CAO2,#, BO ZHU3, YANNI JIANG3, PENGCHONG LIANG3,*
BIOCELL, Vol.45, No.1, pp. 41-48, 2021, DOI:10.32604/biocell.2021.010454
- 26 January 2021
Abstract Glycosylation of mucins mediated by N-acetylgalactosaminyltransferases (GALNTs) is closely related to
respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). In addition, long non-coding
RNAs (LncRNAs) participate in physiological and pathological processes through various epigenetic mechanisms. In
this study, we found that a novel LncRNA named NKILA combined with multiple mucins and GALNTs potentially
by several bioinformatics methods, and we used quantitative real-time PCR (RT-qPCR) to detect the expressions of
NKILA, MUC5AC, MUC5B, and GALNT2 mRNA in 50 cases of asthma samples and 19 cases of normal samples,
whose results showed that the… More >
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