Peizhen Yang*, Dezhong Sun*, Fei Jiang†
Oncology Research, Vol.26, No.6, pp. 941-948, 2018, DOI:10.3727/096504018X15149775533331
Abstract Ailanthone (AIL) is a quassinoid isolated from the traditional Chinese medicinal herb Ailanthus altissima.
The antitumor activities of AIL have been reported in several cancers. The purpose of the present study was
to explore the effect of AIL on vestibular schwannomas (VSs). Various concentrations of AIL (0–1 µM) were
used to treat human primary VS cells, and then cell viability, proliferation, apoptosis, and autophagy were
assessed. Expression of miR-21 in VS cells was altered by miRNA transfection. The functional actions of AIL
on miR-21 dysregulated cells were also assessed. AIL significantly reduced the viability of VS… More >
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