CHAO WANG1,2, JUNWEI WANG1, FANQIAN SONG1,2, HANRUO LIU3, LIYAO SUN1,2, XI WEI1,2, TAO ZHENG1, HUA QIAN2, XIAOGUANG LI2, WEIHUA ZHANG4, XIANLING TANG1,*, PING LIU1,*
BIOCELL, Vol.47, No.1, pp. 143-154, 2023, DOI:10.32604/biocell.2023.023585
- 26 September 2022
Abstract Objective: Age-relate cataract (ARC) is a disease of the eyes with no effective drugs to prevent or treat patients.
The aim of the present study is to determine whether histone H3, αA-crystallin (CRYAA), β-galactosidase (GLB1), and
p53 are involved in the pathogenesis of ARC. Methods: A total of 99 anterior lens capsules (ALCs) of patients with ARC
of various nuclear grades, ultraviolet models of ALCs, and two human lens epithelial cell lines (FHL-124 and SRA01/04)
were used, and the expression of histone H3, CRYAA, GLB1, and p53 were detected by immunoblotting and reverse
transcription and real time-quantitative… More >
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