YUQIN YIN1,2,#, YU WU1,#, HONGLIANG HUANG1,2, YINGYING DUAN1,2, ZHONGWEN YUAN1,2, LIHUI CAO1,2, JINJIN YING1,2, YONGHENG ZHOU3,*, SENLING FENG1,2,*
Oncology Research, Vol.32, No.12, pp. 1891-1902, 2024, DOI:10.32604/or.2024.048778
- 13 November 2024
Abstract Background: Polymethoxylated flavones (PMFs) are compounds present in citrus peels and other Rutaceae plants, which exhibit diverse biological activities, including robust antitumor and antioxidant effects. However, the mechanism of PMFs in reversing drug resistance to colon cancer remains unknown. In the present study, we aimed to investigate the potential connection between the aerobic glycolysis-ROS-autophagy signaling axis and the reversal of PTX resistance in colon cancer by PMFs. Methods: MTT Cell viability assay and colony formation assay were used to investigate the effect of PMFs combined with PTX in reversing HCT8/T cell resistance ex vivo; the mRNA… More >
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