Federico Greco^1,2,*, Marco Cataldo³, Valerio D’Andrea^2,4, Luca Pugliese⁵, Andrea Panunzio⁶, Alessandro Tafuri⁶, Bruno Beomonte Zobel^2,4, Carlo Augusto Mallio^2,4

Canadian Journal of Urology, Vol.32, No.5, pp. 433-443, 2025, DOI:10.32604/cju.2025.068390 - 30 October 2025

Abstract Background: Radiogenomics offers a non-invasive approach to correlate imaging features with tumor molecular profiles. This study aims to identify computed tomography (CT) imaging characteristics associated with positive NIPA-like domain containing 4 (NIPAL4) expression in clear cell renal cell carcinoma (ccRCC) and to develop a radiogenomic predictive model to support personalized risk stratification. Methods: A retrospective analysis was conducted on 241 ccRCC patients from The Cancer Genome Atlas (TCGA) and The Cancer Imaging Archive (TCIA) databases. Clinical, pathological, and CT features were compared between NIPAL4-positive and NIPAL4-negative groups. A penalized logistic regression model was built to… More >

YUN WANG¹, XIAOJIANG LI², DALONG LIU², ZHIFENG WANG³, JICHEN XIA⁴, LIJUN WANG⁵, XUDONG ZHANG^6,*

Oncology Research, Vol.32, No.10, pp. 1649-1660, 2024, DOI:10.32604/or.2024.043482 - 18 September 2024

Abstract Exosomes, minute vesicles ubiquitously released by diverse cell types, serve as critical mediators in intercellular communication. Their pathophysiological relevance, especially in malignancies, has garnered significant attention. A meticulous exploration of the exosomal impact on cancer development has unveiled avenues for innovative and clinically valuable techniques. The cargo conveyed by exosomes exerts transformative effects on both local and distant microenvironments, thereby influencing a broad spectrum of biological responses in recipient cells. These membrane-bound extracellular vesicles (EVs) play a pivotal role in delivering bioactive molecules among cells and organs. Cellular and biological processes in recipient cells, ranging… More > Graphic Abstract

YARA ALZGHOUL, HALA J. BANI ISSA, AHMAD K. SANAJLEH, TAQWA ALABDUH, FATIMAH RABABAH, MAHA AL-SHDAIFAT, EJLAL ABU-EL-RUB^*, FATIMAH ALMAHASNEH, RAMADA R. KHASAWNEH, AYMAN ALZU’BI, HUTHAIFA MAGABLEH

BIOCELL, Vol.48, No.4, pp. 559-569, 2024, DOI:10.32604/biocell.2024.048056 - 09 April 2024

Abstract Mesenchymal stem cells (MSCs) are ideal candidates for treating many cardiovascular diseases. MSCs can modify the internal cardiac microenvironment to facilitate their immunomodulatory and differentiation abilities, which are essential to restore heart function. MSCs can be easily isolated from different sources, including bone marrow, adipose tissues, umbilical cord, and dental pulp. MSCs from various sources differ in their regenerative and therapeutic abilities for cardiovascular disorders. In this review, we will summarize the therapeutic potential of each MSC source for heart diseases and highlight the possible molecular mechanisms of each source to restore cardiac function. More >

Michael Uy¹, Richard Di Lena¹, Jen Hoogenes^1,2, Badr Al-Harbi³, Aidan Woodward⁴, Bobby Shayegan^1,2, Edward D. Matsumoto^1,2

Canadian Journal of Urology, Vol.29, No.1, pp. 11005-11011, 2022

Abstract Introduction: The relationship between obesity and nephrolithiasis is a well-documented phenomenon. Visceral adipose tissue (VAT) has been proposed to be an accurate indicator of metabolic derangement. We present a study that investigates the relationship between computed tomography (CT) delineated VAT measurements and 24-hour urine (24 HU) profiles in the context of profound weight loss.
Materials and methods: A total of 86 patients with a history of nephrolithiasis who underwent bariatric surgery were reviewed. All patients had pre and postoperative 24 HU analysis and CT kidney and urinary bladder performed. CT-based fat delineation program, AnalyzePro, was used to… More >

JÉRÔME LALOZE^1,2, ALEXIS DESMOULIÈRE^1,*

BIOCELL, Vol.46, No.12, pp. 2701-2704, 2022, DOI:10.32604/biocell.2022.022229 - 10 August 2022

Abstract Advances in regenerative medicine correlate strongly with progress in the use of adipose tissue-derived mesenchymal stem/stromal cells. The range of therapeutic indications has also expanded over recent years. Numerous recent studies have highlighted the primary importance of paracrine secretion by these cells. Though it is interesting to compare the different types of such secretions, we believe that exosomes (extra-cellular vesicles possessing the same properties as their source cells) will likely be the main key in tomorrow’s cell therapy. Exosomes also have many advantages compared to the direct use of cells, making these particles a major More >

MIN CHEN^1,#, YUAN HUANG^2,#, WEN XU², CHUNLIN SU^2,*

BIOCELL, Vol.46, No.6, pp. 1505-1519, 2022, DOI:10.32604/biocell.2022.016564 - 07 February 2022

Abstract The development of polycystic ovary syndrome (PCOS) is closely related to the chronic inflammatory and obese. Recent studies have found macrophages regulate the chronic inflammation and adipose tissue remodelling, but the underlying mechanisms have not been clarified. In this study, we established a model of PCOS in the offspring rats by high androgen exposure during late pregnancy in parental and established a female rat macrophage eliminating model by rejection of clodronate liposome. Then, the offspring rat macrophage phenotype in offspring female rat adipose tissue, and levels of testosterone, angiogenic factors (PDGF and VEGF) and inflammatory… More >

KSENIJA VELICKOVIC^1,2,#, HILDA ANAID LUGO LEIJA^1,3,#, SARAH MCGINLAY^1,3,#, MICHAEL E. SYMONDS^1,3, VIRGINIE SOTTILE^1,4,*

BIOCELL, Vol.44, No.4, pp. 501-512, 2020, DOI:10.32604/biocell.2020.012942 - 24 December 2020

Abstract Temperature is a key regulator of brown adipose tissue (BAT) function, acting through central sensory inputs to influence metabolism and energy storage. Although animal models have produced a wealth of information on the pathways, effectors and responses mediating the physiological response of adipose tissue to temperature in vivo, the use of cell culture models now offers evidence of an additional cell-autonomous response to temperature changes, in the absence of neural input. In particular, stem cell models provide new insight into the regulation of adipogenic differentiation and the induction of browning features in vitro. Here the basis More >

Jacek Karczewski¹, Ewelina Śledzi´ nska², Alina Baturo², Izabela Jończyk³, Aleksander Maleszko³, Paweł Samborski², Beata Begier-Krasińska⁴, Agnieszka Dobrowolska²

European Cytokine Network, Vol.29, No.3, pp. 83-94, 2018, DOI:10.1684/ecn.2018.0415

Abstract The prevalence of obesity has recently increased dramatically and has contributed to the increasing prevalence of various pathological conditions, including type 2 diabetes mellitus, nonalcoholic fatty liver disease, asthma, various types of cancer, cardiovascular and neurodegenerative diseases, and others. Accumulating evidence points to localized inflammation in adipose tissue, which, in turn, promotes systemic low-grade inflammation as a primary force contributing to the development of these pathologies. A better understanding of the underlying mechanisms behind obesity-induced adipose tissue inflammation is required to develop effective therapeutic or prophylactic strategies. This review is aimed to present the current More >

Atefeh Golpaie^1,2, Narges Tajik^1,2, Farzad Masoudkabir³, Zohreh Karbaschian¹, Mohammad Talebpour^2,4, Mostafa Hoseini⁵, Mohammad Javad Hosseinzadeh-Attar^1,2

European Cytokine Network, Vol.22, No.4, pp. 181-186, 2011, DOI:10.1684/ecn.2011.0295

Abstract Background. The aims of this study were to evaluate the short-term effects of laparoscopic restrictive bariatric surgery (LRBS) on plasma levels of vaspin and the potential associations of changes in vaspin levels with changes in anthropometric indices, insulin-resistance and dietary intake. Methods. Thirty, severely obese subjects (21 female; mean age, 32.5 years) with a mean body mass index (BMI) of 44.1 ± 4.9 kg/m² underwent LRBS. Measurements of anthropometric indices, dietary intakes, physical activity and plasma vaspin concentrations were performed prior to, and six weeks after LRBS. Insulin-sensitivity was estimated using the homeostasis model assessment of… More >

Claudia Ress¹, Alexander Tschoner¹, Christian Ciardi¹, Markus W. Laimer¹, Julia W. Engl¹, Wolfgang Sturm¹, Helmut Weiss², Herbert Tilg³, Christoph F. Ebenbichler¹, Josef R. Patsch¹, Susanne Kaser¹

European Cytokine Network, Vol.21, No.1, pp. 65-70, 2010, DOI:10.1684/ecn.2009.0177

Abstract Background. Matrix metalloproteinases (MMPs) and their specific inhibitors (tissue inhibitor of metalloproteinases [TIMPs]), are involved in adipogenesis, angiogenesis and remodeling of extracellular matrix. MMPs and TIMPs have been shown to be associated with various diseases such as neurological disorders, malig-nancies and cardiovascular disease. MMPs and TIMPs are thought to play a major role in extensive reorganization of the adipose tissue in obesity. Methods and materials. To test whether significant weight loss alters circulating MMPs and TIMPs, 18 morbidly obese women, who underwent bariatric surgery for weight loss, were investigated before and one year after surgery… More >