MARYNA TKACHENKO¹, ANATOLII ONISHCHENKO², LILIYA TRYFONYUK³, DMYTRO BUTOV⁴, KATERYNA KOT⁵, VIKTORIIA NOVIKOVA⁶, LIWEI FAN^5,7, VOLODYMYR PROKOPIUK^2,8, YURII KOT^5,*, ANTON TKACHENKO^2,*

BIOCELL, Vol.48, No.8, pp. 1197-1208, 2024, DOI:10.32604/biocell.2024.050206 - 02 August 2024

Abstract Introduction: Human chemerin is an adipokine that regulates chemotaxis, inflammation, and glucose metabolism. In addition, accumulating evidence suggests that chemerin promotes apoptosis, autophagy, and pyroptosis. However, there are no data on its impact on eryptosis. The current study aimed to analyze the effects of human active Glu-Ser chemerin on eryptosis in vitro. Materials and Methods: Human chemerin 0-2-10-50 µg/mL was incubated for 24 h with human erythrocytes (hematocrit 0.4%) obtained from eight healthy individuals. Flow cytometry-based determination of phospholipid scrambling, reactive oxygen species (ROS) production, and intracellular Ca levels was performed. To supplement data on ROS and Ca… More >

Yaelle Elfassy^1,2,a, Chloe McAvoy^2,a, Soraya Fellahi^2,3, Joëlle Dupont⁴, Bruno Fève^2,5, Rachel Levy^1,2, Jean-Philippe Bastard^2,3

European Cytokine Network, Vol.28, No.4, pp. 141-150, 2017, DOI:10.1684/ecn.2018.0403

Abstract Infertility, which increased worldwide over the past few decades, has recently been linked to obesity prevalence. Adipokines, produced by adipose tissue, could be the link between obesity and infertility. The association between circulating adipokines and female infertility has been extensively studied in the last ten years. However, the male aspect has been less investigated, although some adipokines are present in seminal plasma. We have attempted to analyze published studies that measured seminal plasma adipokines and their relationships with semen parameters. Apart from leptin, other seminal adipokines have rarely been studied. Indeed, leptin seems to have More >

İlhan Tarkun¹, Emre Dikmen², Berrin Çetinarslan¹, Zeynep Cantürk¹

European Cytokine Network, Vol.21, No.4, pp. 272-277, 2010, DOI:10.1684/ecn.2010.0217

Abstract Background. Adipose tissue synthesizes various adipokines such as resistin, adiponectin and visfa-tin, which have an effect on insulin resistance. This study was designed to show the effect of metformin, one of the most important drugs used to reduce insulin resistance in patients with polycystic ovary syndrome (PCOS), on these adipokines. Methods. The study group consisted of 24 women with PCOS and 25 healthy, age- and weight-matched, normally menstruating women. Hormone and lipid profiles, visfatin, adiponectin and resistin were measured in all cases, before and after metformin treatment. Results. Serum visfatin levels were found to be… More >