Shuye Lin*†, Bonan Lin*, Xiaoyue Wang*, Yuanming Pan‡, Qing Xu*, Jin-Shen He*, Wanghua Gong§, Rui Xing‡, Yuqi He¶, Lihua Guo*, Youyong Lu‡, Ji Ming Wang†, Jiaqiang Huang*†
Oncology Research, Vol.25, No.3, pp. 317-329, 2017, DOI:10.3727/096504016X14734735156265
Abstract The ATPase H+/K+
Transporting Beta Subunit (ATP4B) encodes the b subunit of the gastric H+, K+
-ATPase,
which controls gastric acid secretion and is therefore a target for acid reduction. Downregulation of ATP4B was
recently observed in human gastric cancer (GC) without known mechanisms. In the present study, we demonstrated that ATP4B expression was decreased in human GC tissues and cell lines associated with DNA hypermethylation and histone hypoacetylation of histone H3 lysine 9 at its intragenic region close to the transcriptional
start site. The expression of ATP4B was restored in GC cell lines by treatment with… More >
Login
Register
