Wunchana Seubwai*†‡, Kulthida Vaeteewoottacharn‡§, Ratthaphol Kraiklang¶,
Kazuo Umezawa#, Seiji Okada**, Sopit Wongkham‡§
Oncology Research, Vol.23, No.1-2, pp. 21-28, 2015, DOI:10.3727/096504015X14424348426071
Abstract Cholangiocarcinoma (CCA) is a dismal cancer. At present, there is no effective chemotherapeutic regimen
for CCA. This may be due to the marked resistance of CCA to chemotherapy drugs, for which a mechanism
remains unknown. Nuclear factor-kB (NF-kB) is constitutively activated in a variety of cancer cells, including
CCA. It has been shown to play roles in growth, metastasis, and chemoresistance of cancer. In the present study,
we examined whether NF-kB is involved in the chemoresistance of CCA and whether dehydroxymethylepoxyquinomicin (DHMEQ), an effective NF-kB inhibitor, can overcome the drug resistance of CCA. Two CCA… More >
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