Olanrewaju M. Oyewola^1,*, Olawale S. Ismail², Adetokunbo A. Awonusi²

Frontiers in Heat and Mass Transfer, Vol.22, No.2, pp. 475-490, 2024, DOI:10.32604/fhmt.2024.047714 - 20 May 2024

Abstract One of the new methods for ensuring that the battery in a thermal energy storage system is kept at the proper temperature is the heat pipe-based Thermal Management System (TMS). In this study, the improvement of cooling performance of a heat pipe based TMS is examined through the variation of condenser section length of heat pipes in an array. The TMSs with an array of heat pipes with different condenser section lengths are considered. The system performances are evaluated using a validated numerical method. The results show that a heat pipe-based TMS provides the best More >

SHAHID KARIM^1,*, ALANOUD NAHER ALGHANMI¹, MAHA JAMAL¹, HUDA ALKREATHY¹, ALAM JAMAL², HIND A. ALKHATABI³, MOHAMMED BAZUHAIR¹, AFTAB AHMAD^4,5

Oncology Research, Vol.32, No.5, pp. 817-830, 2024, DOI:10.32604/or.2024.048988 - 23 April 2024

Abstract Cancer frequently develops resistance to the majority of chemotherapy treatments. This study aimed to examine the synergistic cytotoxic and antitumor effects of SGLT2 inhibitors, specifically Canagliflozin (CAN), Dapagliflozin (DAP), Empagliflozin (EMP), and Doxorubicin (DOX), using in vitro experimentation. The precise combination of CAN+DOX has been found to greatly enhance the cytotoxic effects of doxorubicin (DOX) in MCF-7 cells. Interestingly, it was shown that cancer cells exhibit an increased demand for glucose and ATP in order to support their growth. Notably, when these medications were combined with DOX, there was a considerable inhibition of glucose consumption, as More > Graphic Abstract

Sophea Horng, Pisal Yenradee^*

CMC-Computers, Materials & Continua, Vol.75, No.3, pp. 6119-6143, 2023, DOI:10.32604/cmc.2023.038764 - 29 April 2023

Abstract This paper proposes a Delivery Service Management (DSM) system for Small and Medium Enterprises (SMEs) that own a delivery fleet of pickup trucks to manage Business-to-Business (B2B) delivery services. The proposed DSM system integrates four systems: Delivery Location Positioning (DLP), Delivery Route Planning (DRP), Arrival Time Prediction (ATP), and Communication and Data Sharing (CDS) systems. These systems are used to pinpoint the delivery locations of customers, plan the delivery route of each truck, predict arrival time (with an interval) at each delivery location, and communicate and share information among stakeholders, respectively. The DSM system deploys… More >

Emad Abd Al Rahman¹, Nur Intan Raihana Ruhaiyem^1,*, Majed Bouchahma², Kamarul Imran Musa³

Intelligent Automation & Soft Computing, Vol.36, No.3, pp. 3007-3028, 2023, DOI:10.32604/iasc.2023.032580 - 15 March 2023

Abstract This study offers a framework for a breast cancer computer-aided treatment prediction (CATP) system. The rising death rate among women due to breast cancer is a worldwide health concern that can only be addressed by early diagnosis and frequent screening. Mammography has been the most utilized breast imaging technique to date. Radiologists have begun to use computer-aided detection and diagnosis (CAD) systems to improve the accuracy of breast cancer diagnosis by minimizing human errors. Despite the progress of artificial intelligence (AI) in the medical field, this study indicates that systems that can anticipate a treatment… More >

Raed Alhamad^1,*, Hatem Boujemaa²

Computer Systems Science and Engineering, Vol.45, No.2, pp. 2059-2070, 2023, DOI:10.32604/csse.2023.032610 - 03 November 2022

Abstract In this article, we use Intelligent Reflecting Surfaces (IRS) to improve the throughput of Non Orthogonal Multiple Access (NOMA) with Adaptive Transmit Power (ATP). The results are valid for Cognitive Radio Networks (CRN) where secondary source adapts its power to generate low interference at primary receiver. In all previous studies, IRS were implemented with fixed transmit power and previous results are not valid when the power of the secondary source is adaptive. In CRN, secondary nodes are allowed to transmit over the same band as primary users since they adapt their power to minimize the More >

LUPING YANG^1,#, YIJING JIANG^2,#, XIAOQIAN YE^3,#, YONGMEI YOU², LING LIN², JING LIAN², JUAN LI¹, SHANLI YANG², XIEHUA XUE²

BIOCELL, Vol.46, No.1, pp. 235-245, 2022, DOI:10.32604/biocell.2022.014997 - 28 September 2021

Abstract ATP depletion is one of the pathological bases in cerebral ischemia. Electro-acupuncture (EA) is widely used in clinical practice for ischemia. However, the mechanism of EA remains unclear. The purpose of this study was to investigate whether EA could activate the AMPK/PGC-1α/TFAM signaling pathway and, consequently, increase the preservation of ATP in rats with ischemia. In this study, 48 rats were randomly divided into four groups as a sham-operation control group (sham group), a middle cerebral artery occlusion group (MCAO group), an EA group, and an EA group blocked by the AMPK inhibitor compound C… More >

Zhenzhen SHI, Jiaxin CAO, Hailong PANG, Lingyun JIA, Kun SUN, Hanqing FENG^*

BIOCELL, Vol.44, No.1, pp. 89-99, 2020, DOI:10.32604/biocell.2020.08059 - 01 March 2020

Abstract Cadmium (Cd) is one of the most widespread and toxic heavy metals to plants. Extracellular ATP (exATP) is thought to be an extracellular effector in regulating the physiological responses of plant cells to environmental stresses. However, the function of exATP in Cd-stressed plant cells is much unknown. The present work showed that treating tobacco (Nicotiana tabacum L. cv. Bright Yellow-2) cell-suspension cultures with exogenous CdCl₂ reduced the cell viability, exATP level, and Mg content. However, the production of reactive oxygen species (ROS), Cd content, and electrolyte leakage of the cells were enhanced by exogenous CdCl₂. When the… More >

Yan Zu^1,2, Qiang Li¹, Chun Yang^2,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 106-106, 2019, DOI:10.32604/mcb.2019.07132

Abstract Extracellular matrix (ECM) elasticity affects the function of a variety of cells. Integrins are transmembrane receptors that considered to be a sensor of cellular mechanical stimulation. The activity of integrins is strongly influenced by glycans through glycosylation events and the establishment of glycan-mediated interactions. Our study found that the level of β1 integrin N-linked glycosylation was significantly down-regulated on softer ECM. Further, sialic acid is a common monosaccharide modified at the end of the sugar chain during N-glycosylation. We subjected the enriched sialylated glycoproteins to gel-based proteomic identification by tandem mass spectrometry and found that… More >

Mahmoud MOUSTAFA^1,2, Saad ALAMRI¹, Hoida ZAKI², Naglaa LOUTFY², Tarek TAHA³, Ali SHATI¹, Mohamed ALKAHTANI¹, Sajda SIDDIQI¹

BIOCELL, Vol.43, No.2, pp. 81-88, 2019, DOI:10.32604/biocell.2019.06231

Abstract The present research reports of quick and marked changes induced by plant extract of Euryops arabicus in the gene expression of 49-kDa apyrases, cytoskeletal proteins, ATPases, ADPase and amount of amino acid of pea (Pisum sativum L. var. Alaska). Pellets of cytoskeletals proteins (27000 xg) were probed with anti-apyrase antibody, biotinylated anti-rat, actin and alpha and beta-tubulin for Western blotting. ATPase and ADPase activities were determined based on the hydrolytic efficacy of adenine triphosphate and adenine diphosphate. By 72 hours, the abundance of apyrases, cytoskeletal proteins and amount of amino acid in pellets of 27000 xg… More >

Shuye Lin^*†, Bonan Lin^*, Xiaoyue Wang^*, Yuanming Pan^‡, Qing Xu^*, Jin-Shen He^*, Wanghua Gong^§, Rui Xing^‡, Yuqi He^¶, Lihua Guo^*, Youyong Lu^‡, Ji Ming Wang^†, Jiaqiang Huang^*†

Oncology Research, Vol.25, No.3, pp. 317-329, 2017, DOI:10.3727/096504016X14734735156265

Abstract The ATPase H⁺/K⁺ Transporting Beta Subunit (ATP4B) encodes the b subunit of the gastric H⁺, K⁺ -ATPase, which controls gastric acid secretion and is therefore a target for acid reduction. Downregulation of ATP4B was recently observed in human gastric cancer (GC) without known mechanisms. In the present study, we demonstrated that ATP4B expression was decreased in human GC tissues and cell lines associated with DNA hypermethylation and histone hypoacetylation of histone H3 lysine 9 at its intragenic region close to the transcriptional start site. The expression of ATP4B was restored in GC cell lines by treatment with… More >