Zhuang Kun*†, Guo Hanqing*, Tang Hailing*, Yan Yuan*, Zhang Jun†, Zhang Lingxia*, Han Kun*, Zhang Xin*
Oncology Research, Vol.25, No.8, pp. 1399-1407, 2017, DOI:10.3727/096504016X14823648620870
Abstract Gastric cancer (GC) is one of the most frequent epithelial malignancies worldwide. The gastrointestinal (GI)
peptide gastrin is an important regulator of the secretion and release of gastric acid from stomach parietal
cells, and it also plays a vital role in the development and progression of GC. The aim of the current study
was to investigate the role and underlying mechanism of gastrin and autophagy in regulating GC tumorigenesis. Gastrin-17 amide (G-17) was applied in the GC cell lines SGC7901 and MGC-803. The results showed
that G-17 maintained the high viability of SGC7901 and MGC-803.… More >
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