Jiangyang Yuan¹, Jiaowen Wu¹, Yi Gao¹, Yuhao Fu², Yuntao Bu², Tianyu Chen², Hao Yu^2,*

Energy Engineering, Vol.123, No.2, 2026, DOI:10.32604/ee.2025.070715 - 27 January 2026

Abstract In the pursuit of carbon peaking and neutrality goals, multi-energy parks, as major energy consumers and carbon emitters, urgently require low-carbon operational strategies. This paper proposes an electricity-carbon synergy-driven optimization method for the low-carbon operation of multi-energy parks. The method integrates multi-energy complementary scheduling with a tiered carbon trading mechanism to balance operational security, economic efficiency, and environmental objectives. A mixed-integer linear programming model is developed to characterize the coupling relationships and dynamic behaviors of key equipment, including photovoltaic systems, ground-source heat pumps, thermal storage electric boilers, combined heat and power units, and electrical energy… More >

Xinyang Li^1,2,3,#, Luyuan Ma^1,2,3,#, Chuan Shen^1,2,3, Ruolan Gu^1,2,3, Shilong Dong^1,2,3, Mingjie Liu^1,2,3, Ying Xiao^1,2,3, Wenpeng Liu^1,2,3, Yuexia Liu^1,2,3, Caiyan Zhao^1,2,3,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.073179 - 19 January 2026

Abstract Background: Hepatocellular carcinoma (HCC) is an aggressive and lethal malignancy. Metabolic reprogramming dynamically remodels the tumor microenvironment (TME) and drives HCC progression. This study investigated the mechanism through which metabolic reprogramming remodels the TME in HCC. Methods: HCC patient transcriptome data were subjected to bioinformatics analysis to identify differentially expressed genes and immune infiltration status. Immunohistochemical analysis was performed to determine the correlation between succinate dehydrogenase complex subunit A (SDHA) expression and M2 macrophage infiltration. SDHA-knockdown or SDHA-overexpressing HCC cells were used for in vitro experiments, including co-culturing, flow cytometry, and enzyme-linked immunosorbent assay. Western blotting… More >

Dongchi Cai^1,2,#, Jialin Ji^3,#, Chunhui Yang^1,*, Hong Cai^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.071152 - 30 December 2025

Abstract Metabolic reprogramming involving branched-chain amino acids (BCAAs)—leucine, isoleucine, and valine—is increasingly recognized as pivotal in cancer progression, metastasis, and immune modulation. This review comprehensively explores how cancer cells rewire BCAA metabolism to enhance proliferation, survival, and therapy resistance. Tumors manipulate BCAA uptake and catabolism via high expression of transporters like L-type amino acid transporter 1 (LAT1) and enzymes including branched chain amino acid transaminase 1(BCAT1), branched chain amino acid transaminase 2 (BCAT2), branched-chain alpha-keto acid dehydrogenase (BCKDH), and branched chain alpha-keto acid dehydrogenase kinase (BCKDK). These alterations sustain energy production, biosynthesis, redox homeostasis, and oncogenic… More >

Jing Cai^1,#, Haoyun Zhu^1,#, Weiling Guo¹, Ting Huang¹, Pangzhou Chen^1,2, Wen Zhou¹, Ziyun Guan^1,3,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.069902 - 30 December 2025

Abstract Background: Therapeutic responses of breast cancer vary among patients and lead to drug resistance and recurrence due to the heterogeneity. Current preclinical models, however, are inadequate for predicting individual patient responses towards different drugs. This study aimed to investigate the patient-derived breast cancer culture models for drug sensitivity evaluations. Methods: Tumor and adjacent tissues from female breast cancer patients were collected during surgery. Patient-derived breast cancer cells were cultured using the conditional reprogramming technique to establish 2D models. The obtained patient-derived conditional reprogramming breast cancer (CRBC) cells were subsequently embedded in alginate-gelatin methacryloyl hydrogel microspheres… More >

Mohamed Kouki¹, Nahid Osman², Mona Gafar³, Ragab A. El-Sehiemy^4,5,6,*

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.3, pp. 3783-3811, 2025, DOI:10.32604/cmes.2025.071964 - 23 December 2025

Abstract The growing integration of nondispatchable renewable energy sources (PV, wind) and the need to cut CO2 emissions make energy management crucial. Microgrids provide a framework for RES integration but face challenges from intermittency, fluctuating loads, cost optimization, and uncertainty in real-time balancing. Accurate short-term forecasting of solar generation and demand is vital for reliable and sustainable operation. While stochastic and machine learning methods are used, they struggle with limited data, complex temporal patterns, and scalability. Key challenges include capturing seasonal to weekly variations and modeling sudden fluctuations in generation and consumption. To address… More >

Bruno Špiljak^1,#, Bojan Poposki^2,#, Stjepanka Lešić^3,*

Oncology Research, Vol.33, No.11, pp. 3269-3292, 2025, DOI:10.32604/or.2025.068395 - 22 October 2025

Abstract Head and neck squamous cell carcinoma (HNSCC) is an aggressive cancer with high recurrence rates and prevalent resistance to therapeutic interventions. Tumor behavior is largely dependent on the tumor microenvironment (TME) that includes immune cells, stromal components, cancer-associated fibroblasts (CAFs), the extracellular matrix (ECM), and an associated cytokine network. In this review, we examine principal mechanisms of the tumorigenic transformation, encompassing immune checkpoint disruption, therapy resistance mediated through CAFs, the contribution of hypoxic niches, and several metabolic dependencies that hold potential as future targets. Novel therapeutics developed and/or repurposed, such as immune checkpoint inhibitors (ICIs),… More >

Minseo Hong, Jea-Hyun Baek^*

Oncology Research, Vol.33, No.10, pp. 2699-2724, 2025, DOI:10.32604/or.2025.067487 - 26 September 2025

Abstract AMP-activated protein kinase (AMPK) is a highly conserved serine/threonine kinase that functions as a central regulator of cellular energy status. In cancer, where metabolic reprogramming enables rapid proliferation and survival under stress, AMPK functions as a metabolic checkpoint that restrains tumor growth by inhibiting biosynthetic pathways and promoting catabolic processes, such as autophagy and fatty acid oxidation. Given its role in opposing many hallmarks of cancer metabolism, AMPK has attracted significant interest as a therapeutic target. This review examines the molecular mechanisms by which AMPK influences tumor progression and evaluates the preclinical and clinical evidence… More >

Elyson De La Cruz^*, Hanh Le, Karthik Meduri, Geeta Sandeep Nadella^*, Hari Gonaygunta

CMC-Computers, Materials & Continua, Vol.85, No.2, pp. 3569-3582, 2025, DOI:10.32604/cmc.2025.068137 - 23 September 2025

Abstract The rapid integration of artificial intelligence (AI) into software development, driven by large language models (LLMs), is reshaping the role of programmers from traditional coders into strategic collaborators within Industry 4.0 ecosystems. This qualitative study employs a hermeneutic phenomenological approach to explore the lived experiences of Information Technology (IT) professionals as they navigate a dynamic technological landscape marked by intelligent automation, shifting professional identities, and emerging ethical concerns. Findings indicate that developers are actively adapting to AI-augmented environments by engaging in continuous upskilling, prompt engineering, interdisciplinary collaboration, and heightened ethical awareness. However, participants also voiced… More >

Tong Wu^*, Dawei Zhou

CMC-Computers, Materials & Continua, Vol.85, No.2, pp. 3067-3094, 2025, DOI:10.32604/cmc.2025.066525 - 23 September 2025

Abstract Fault attacks have emerged as an increasingly effective approach for integrated circuit security attacks due to their short execution time and minimal data requirement. However, the lack of a unified leakage model remains a critical challenge, as existing methods often rely on algorithm-specific details or prior knowledge of plaintexts and intermediate values. This paper proposes the Fault Probability Model based on Hamming Weight (FPHW) to address this. This novel statistical framework quantifies fault attacks by solely analyzing the statistical response of the target device, eliminating the need for attack algorithm details or implementation specifics. Building… More >

Abu Saleh Musa Miah¹, Md Mahbubur Rahman Tusher², Md. Moazzem Hossain², Md Mamun Hossain², Md Abdur Rahim³, Md Ekramul Hamid⁴, Md. Saiful Islam⁴, Jungpil Shin^1,*

CMES-Computer Modeling in Engineering & Sciences, Vol.143, No.3, pp. 2573-2614, 2025, DOI:10.32604/cmes.2025.064168 - 30 June 2025

Abstract Advanced artificial intelligence technologies such as ChatGPT and other large language models (LLMs) have significantly impacted fields such as education and research in recent years. ChatGPT benefits students and educators by providing personalized feedback, facilitating interactive learning, and introducing innovative teaching methods. While many researchers have studied ChatGPT across various subject domains, few analyses have focused on the engineering domain, particularly in addressing the risks of academic dishonesty and potential declines in critical thinking skills. To address this gap, this study explores both the opportunities and limitations of ChatGPT in engineering contexts through a two-part… More >