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  • Open Access

    REVIEW

    The roles and mechanisms of miRNA in HBV-HCC carcinogenesis: Why no therapeutic agents after 30 years?

    KURT SARTORIUS1,2,3,*, BENN SARTORIUS4, CHERIE WINKLER5, ANIL CHUTURGOON2, ANNA KRAMVIS1, PING AN5, WEIGANG ZHANG6, YUNJIE LU3,6,7,*

    BIOCELL, Vol.48, No.11, pp. 1543-1567, 2024, DOI:10.32604/biocell.2024.055505 - 07 November 2024

    Abstract Hepatitis B-associated hepatocellular carcinoma (HBV-HCC) remains an intractable high-mortality solid tumor cancer that accounted for 42% of global HCC cases in 2019. Despite some developments in systemic therapy, only a small subset of late-stage HCC patients responds positively to recently developed therapeutic innovations. MicroRNAs (miRNAs) act as an ancillary epigenetic system that can regulate genome expression in all cancer pathways including HCC. The molecular mechanisms of miRNA regulation in cancer pathogenesis offered researchers a new approach that was widely hoped would translate into miRNA-based drugs and diagnostics. Thirty years on, miRNA-based diagnostic and therapeutic agents… More >

  • Open Access

    ARTICLE

    Standardized Management of Acute Pulmonary Hemorrhage after Percutaneous Pulmonary Vein Intervention

    Catalina Vargas-Acevedo1, Gareth J. Morgan1, Rhynn Soderstrom2, Richard Ing3, Nicholas Houska3, Jenny E. Zablah1,*

    Congenital Heart Disease, Vol.19, No.4, pp. 389-397, 2024, DOI:10.32604/chd.2024.055121 - 31 October 2024

    Abstract Introduction: Pulmonary hemorrhage (PHm) is a life-threatening complication that can occur after catheter-based interventions in patients with pulmonary vein stenosis (PVS). Inhaled racemic epinephrine (iRE) and tranexamic acid (iTXA) have been used in other conditions, but a standardized approach in PVS has not been described. We aimed to describe the current management of PHm after PVS catheter-based interventions. Methods: We present a retrospective review of episodes of PHm from July 2022 to February 2024. PHm was defined as frank blood suctioned from the endotracheal tube including blood-tinged secretions and >3% decrease in saturations and/or ventilatory… More >

  • Open Access

    REVIEW

    The Effects of Laser Therapy in Treating Hypertrophic Scars and Keloids after Median Sternotomy: A Scoping Review

    Laura Schianchi1,*, Fabrizio Vaira2, Massimo Chessa1,3, Serena Francesca Flocco4, Arianna Magon4, Gianluca Conte4, Karina Geraldina Zuniga Olaya5, Giacomo Bortolussi6, Erika Cioffi1, Matteo Riccardo Di Nicola2, Santo Raffaele Mercuri2, Rosario Caruso4,7

    Congenital Heart Disease, Vol.19, No.4, pp. 363-374, 2024, DOI:10.32604/chd.2024.053999 - 31 October 2024

    Abstract Background: Hypertrophic scars and keloids, common complications following median sternotomy for cardiac surgery, significantly impact patient quality of life due to their aesthetic and symptomatic burden. Recent advancements in laser therapy have made it a prominent option for managing these complex scars, yet a comprehensive understanding of its efficacy is lacking. The aim of this scoping review is to explore the effects of laser therapy in managing hypertrophic scars and keloids after median sternotomy. Methods: This scoping review analyzed studies up to February 2024 from databases including PubMed, EMBASE, CINAHL, Scopus, Web of Science, and… More >

  • Open Access

    ARTICLE

    Prospective Cohort Research of Aortic Root Dilatation after Surgical Repair in Adults with Tetralogy of Fallot (TRANSIT)

    Hiroki Nagamine1, Masaru Miura1,*, Jun Maeda1, Takumi Nishiki1, Maasa Sato2, Fumie Takechi3, Shigeru Tateno4, Tomoko Ishizu5, Yumi Shiina6, Ken Kato7, Hiroshi Ono8, Hiroyuki Yamagishi9, Koichiro Niwa6

    Congenital Heart Disease, Vol.19, No.4, pp. 351-362, 2024, DOI:10.32604/chd.2024.051837 - 31 October 2024

    Abstract Background: Aortic root dilatation occurs in adults with tetralogy of Fallot (TOF) after surgical repair, but the longitudinal changes are unclear. The main research aim is to determine the annual dilatation rate of aorta in adults with repaired TOF. Methods: The present, multicentric, prospective cohort study assessed the rate of aortic diameter change in adults aged 20 years or older with TOF, including pulmonary artery atresia, who underwent surgical repair. Clinical data, focusing on echocardiograms, were collected at three-year intervals from seven hospitals. Results: In total, 104 patients (58 males; median age: 29 years) were enrolled.… More > Graphic Abstract

    Prospective Cohort Research of Aortic Root Dilatation after Surgical Repair in Adults with Tetralogy of Fallot (TRANSIT)

  • Open Access

    RETRACTION

  • Open Access

    ARTICLE

    Is ypTNM staging a comparable predictor as pTNM staging for survival in non-metastatic rectal cancer after preoperative chemoradiation therapy?

    JEN-PIN CHUANG1,2,3, HSIANG-LIN TSAI4,5, WEI-CHIH SU4,6,7, PO-JUNG CHEN4,6, CHING-WEN HUANG4,5, TSUNG-KUN CHANG4,6,7, YEN-CHENG CHEN4,6, CHING-CHUN LI4,8, YUNG-SUNG YEH4,9,10, TZU-CHIEH YIN4,5,11, JAW-YUAN WANG4,5,6,12,13,*

    Oncology Research, Vol.32, No.11, pp. 1723-1732, 2024, DOI:10.32604/or.2024.052098 - 16 October 2024

    Abstract Background: The pTNM staging system is widely recognized as the most effective prognostic indicator for cancer. The latest update of this staging system introduced a new pathological staging system (ypTNM) for patients receiving neoadjuvant chemoradiotherapy (NACRT). However, whether the prognostic value of the ypTNM staging system for rectal cancer is similar to that of the pTNM staging system remains unclear. This study was conducted to compare the ypTNM and pTNM staging systems in terms of their prognostic value for patients with nonmetastatic rectal cancer undergoing proctectomy. Material and Methods: This study was conducted at a large teaching… More >

  • Open Access

    PROCEEDINGS

    Numerical Study on the Sloshing and Thermodynamic Characteristics of Liquid Hydrogen Storage Tank in Hydrogen-Powered Aircraft

    Zhibo Chen1, Jingfa Li1,*, Bo Yu1, Jianli Li1, Wei Zhang2

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.29, No.4, pp. 1-1, 2024, DOI:10.32604/icces.2024.011004

    Abstract Using liquid hydrogen as fuel is helpful to the aviation industry to achieve the goal of carbon peak and carbon neutrality. However, the liquid hydrogen storage tank will inevitably slosh during the use inhydrogen-powered aircraft, thus it is necessary to study the thermodynamic characteristics of liquid hydrogen storage tank during the sloshing process. In this paper, the thermodynamic behavior of liquid hydrogen storage tank under external excitation is studied by using Volume of Fluid(VOF) model and Lee model through numerical simulation methods. The changes of pressure and temperature in the process of tank sloshing under… More >

  • Open Access

    ARTICLE

    A Two-Stage Scenario-Based Robust Optimization Model and a Column-Row Generation Method for Integrated Aircraft Maintenance-Routing and Crew Rostering

    Khalilallah Memarzadeh1, Hamed Kazemipoor1,*, Mohammad Fallah1, Babak Farhang Moghaddam2

    CMES-Computer Modeling in Engineering & Sciences, Vol.141, No.2, pp. 1275-1304, 2024, DOI:10.32604/cmes.2024.050306 - 27 September 2024

    Abstract Motivated by a critical issue of airline planning process, this paper addresses a new two-stage scenario-based robust optimization in operational airline planning to cope with uncertainty and possible flight disruptions. Following the route network scheme and generated flight timetables, aircraft maintenance routing and crew scheduling are critical factors in airline planning and operations cost management. This study considers the simultaneous assignment of aircraft fleet and crew to the scheduled flight while satisfying a set of operational constraints, rules, and regulations. Considering multiple locations for airline maintenance and crew bases, we solve the problem of integrated… More > Graphic Abstract

    A Two-Stage Scenario-Based Robust Optimization Model and a Column-Row Generation Method for Integrated Aircraft Maintenance-Routing and Crew Rostering

  • Open Access

    ARTICLE

    Isolation and Characterization of Cellulose Nanofiber (CNF) from Kenaf (Hibiscus cannabinus) Bast through the Chemo-Mechanical Process

    Rudi Dungani1,*, Mohammad Irfan Bakshi2, Tsabita Zahra Hanifa1, Mustika Dewi1, Firda A. Syamani2, Melbi Mahardika2, Widya Fatriasari2,*

    Journal of Renewable Materials, Vol.12, No.6, pp. 1057-1069, 2024, DOI:10.32604/jrm.2024.049342 - 02 August 2024

    Abstract The present work emphasizes the isolation of cellulose nanofiber (CNF) from the kenaf (Hibiscus cannabinus) bast through a chemo-mechanical process. In order to develop high CNF yield with superior properties of CNF for improving compatibility in varied applications this method is proposed. The fiber purification involved pulping and bleaching treatments, whereas mechanical treatment was performed by grinding and high-pressure treatments. The kraft pulping as a delignification method followed by bleaching has successfully removed almost 99% lignin in the fiber with high pulp yield and delignification selectivity. The morphology of the fibers was characterized by scanning electron More > Graphic Abstract

    Isolation and Characterization of Cellulose Nanofiber (CNF) from Kenaf <i>(Hibiscus cannabinus)</i> Bast through the Chemo-Mechanical Process

  • Open Access

    CASE REPORT

    Fate of Right Coronary Artery Occlusion after a Surgically Repaired Aorto-Ventricular Tunnel in a Neonate

    Sherif Negm1,2, Loic Mace1, Fedoua El Louali3, Beatrice Desnous4, Philipe Aldebert3, Virginie Fouilloux1, Marien Lenoir1,*

    Congenital Heart Disease, Vol.19, No.3, pp. 267-273, 2024, DOI:10.32604/chd.2024.051642 - 26 July 2024

    Abstract The aorto-ventricular tunnel is a rare congenital cardiac anomaly. We present a case of aorto-ventricular tunnel diagnosed via fetal echocardiography. Emergency surgery was performed on the 2nd day of life to close the tunnel, located just in front of the right coronary ostium, due to the patient’s unstable health condition. The postoperative period revealed complete occlusion of the right coronary artery. Due to the patient’s stability, we opted not to reintervene on the right coronary artery. The patient fully recovered without the need for further coronary intervention. In cases of patients with an aorto-ventricular tunnel More >

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