Lina Tang1,2, Haiyan Hu2, Yan Zhou2, Yujing Huang2, Yonggang Wang2, Yawen Zhang2, Jinrong Liang2, Zhenxin Wang1,*
Oncologie, Vol.24, No.4, pp. 913-925, 2022, DOI:10.32604/oncologie.2022.026296
Abstract Objective: To investigate the expression of alpha–smooth muscle actin (ACTA2) in osteosarcoma tissues and its
relationship with prognosis. Methods: Prognostic analysis of lung metastasis–related genes in osteosarcoma using
the TCGA database. Single-cell sequencing detected the expression of ACTA2 in 11 osteosarcoma tissues. Paraf-
fin-embedded tissues of 74 osteosarcoma patients treated at the Sixth People’s Hospital of Shanghai Jiao Tong
University from 2014 to 2019 were collected, and tissue microarrays were prepared. ACTA2 expression was
detected and scored by immunohistochemistry. According to the median value of the ACTA2 histochemical
score, 74 patients were divided into two groups, the high-expression group and… More >
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