YU-YAN LAN^1,#, TSUN-CHIH CHENG^2,#, YI-PING LEE³, CHIA-YIH WANG^3,*, BU-MIIN HUANG^3,4,*

BIOCELL, Vol.48, No.7, pp. 1047-1054, 2024, DOI:10.32604/biocell.2024.050701

Abstract Background: Paclitaxel is a compound derived from Pacific yew bark that induces various cancer cell apoptosis. However, whether it also has anticancer activities in KOSC3 cells, an oral cancer cell line, is unclear. Methods: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, flow cytometry, and western blotting assays were carried out to assess cell viability, subG1 phase of the cell cycle, and apoptosis-related protein expression, respectively. Results: Our findings indicate that paclitaxel could inhibit cell viability and increase the expression of apoptotic markers, including plasma membrane blebbing and the cleavage of poly ADP-ribose polymerase in KOSC3 cells. Also, the treatment with paclitaxel More > Graphic Abstract

Michael Kuchinskiy^1,2,*, Tatyana Lyubimova^1,2, Konstantin Rybkin², Anastasiia Sadovnikova², Vasiliy Galishevskiy²

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.5, pp. 1093-1102, 2024, DOI:10.32604/fdmp.2024.050059

Abstract Ultrasonic baths and sonochemical reactors are widely used in industrial applications dealing with surface cleaning and chemical synthesis. The processes of erosion, cleaning and structuring of the surface can be typically controlled by changing relevant influential parameters. In particular, in this work, we experimentally investigate the effect of NaCl concentration (0–5.5 mol/L) on the erosion of an aluminum foil under ultrasonic exposure at a frequency of 28 kHz. Special attention is paid to the determination of cavitation zones and their visualization using heat maps. It is found that at low NaCl concentration (0.3 mol/L), the More > Graphic Abstract

Makoto Akiyama^*†, Yoshihiro Sowa^*, Tomoyuki Taniguchi^*, Motoki Watanabe^*, Shingo Yogosawa^‡, Jo Kitawaki^†,Toshiyuki Sakai^*

Oncology Research, Vol.25, No.8, pp. 1245-1252, 2017, DOI:10.3727/096504017X14850164661097

Abstract Ovarian cancer is the most lethal disease among gynecological malignancies. More effective therapy is required to counter high recurrence rates and chemotherapy resistance. We investigated the efficacy and molecular mechanisms of three combined treatments (TCTs)—a novel histone deacetylase (HDAC) inhibitor OBP-801/YM753, 5-fluorouracil (5-FU), and paclitaxel (PTX)—in human ovarian cancer SKOV-3 and OVCAR-3 cells. The inhibition of cell growth was stronger with TCTs than with each single agent and with two combined treatments. The TCTs significantly induce G₂ phase arrest in both cell lines. We then analyzed the molecular mechanisms and found that the TCTs increased the More >

Yan Zhang, Gang Cao, Qing-gong Yuan, Jun-hui Li, Wen-Bin Yang

Oncology Research, Vol.25, No.4, pp. 537-544, 2017, DOI:10.3727/096504016X14756640150695

Abstract Empty spiracles homeobox 2 (EMX2) is a homeodomain-containing transcription factor that plays an essential role in tumorigenesis. However, to the best of our knowledge, the role of EMX2 in human colorectal cancer (CRC) is still unclear. Thus, the aim of this study was to investigate the expression and role of EMX2 in CRC. Our results demonstrated that the expression of EMX2 was greatly decreased in CRC tissues and cell lines. Overexpression of EMX2 significantly inhibited the proliferation in vitro and CRC tumor growth in nude mice. In addition, EMX2 also inhibited the migration and invasion More >

XIAOQI WU^1,2,#, YECHUAN HE^1,2,#, YEQIN YUAN⁴, XIAN TAN^1,2, LIN ZHU^1,2, DANLING WANG^1,2,4, BINYUAN JIANG^3,4,*

BIOCELL, Vol.48, No.5, pp. 861-872, 2024, DOI:10.32604/biocell.2024.048758

Abstract Background: Nasopharyngeal carcinoma (NPC) exhibits a significant prevalence in the southern regions of China, and paclitaxel (PTX) is frequently employed as a medication for managing advanced NPC. However, drug resistance is typically accompanied by a poor prognosis. Exploring the synergistic potential of combining multiple chemotherapeutic agents may represent a promising avenue for optimizing treatment efficacy. Methods: This study investigated whether 3-Methyladenine (3-MA) could potentiated the effect of PTX and its potential molecular mechanism. Samples were divided into the following categories: Negative control (NC) with the solvent dimethyl sulfoxide (DMSO, 0.5% v/v), PTX (400 nM), 3-MA… More >

LU ZHANG^*, JINGUO CHU^*, YUSHAN YU

Oncology Research, Vol.32, No.4, pp. 703-716, 2024, DOI:10.32604/or.2023.030988

Abstract Background: Limited research has been conducted on the influence of autophagy-associated long non-coding RNAs (ARLncRNAs) on the prognosis of hepatocellular carcinoma (HCC). Methods: We analyzed 371 HCC samples from TCGA, identifying expression networks of ARLncRNAs using autophagy-related genes. Screening for prognostically relevant ARLncRNAs involved univariate Cox regression, Lasso regression, and multivariate Cox regression. A Nomogram was further employed to assess the reliability of Riskscore, calculated from the signatures of screened ARLncRNAs, in predicting outcomes. Additionally, we compared drug sensitivities in patient groups with differing risk levels and investigated potential biological pathways through enrichment analysis, using… More >

Rohollah Fallah Madvari¹, Hamideh Bidel², Ahmad Mehri³, Fatema Babaee⁴, Fereydoon Laal^5,*

Sound & Vibration, Vol.58, pp. 119-131, 2024, DOI:10.32604/sv.2024.048861

Abstract Noise is one of the environmental factors with mental and physical effects. The workload is also the multiple mental and physical demands of the task. Therefore, his study investigated the relationship between noise exposure and mood states at different levels of workload. The study recruited 50 workers from the manufacturing sector (blue-collar workers) as the exposed group and 50 workers from the office sector (white-collar workers) as the control group. Their occupational noise exposure was measured by dosimetry. The Stress-Arousal Checklist (SACL) and the NASA Task Load Index (NASA-TLX) were used to measure mood and… More >

Bingzhu Wang^1,*, Xiangrui Ye^2,*

CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.2, pp. 1401-1425, 2024, DOI:10.32604/cmes.2024.047364

Abstract A novel three-dimensional-fiber reinforced soft pneumatic actuator (3D-FRSPA) inspired by crab claw and human hand structure that can bend and deform independently in each segment is proposed. It has an omni-directional bending configuration, and the fibers twined symmetrically on both sides to improve the bending performance of FRSPA. In this paper, the static and kinematic analysis of 3D-FRSPA are carried out in detail. The effects of fiber, pneumatic chamber and segment length, and circular air chamber radius of 3D-FRSPA on the mechanical performance of the actuator are discussed, respectively. The soft mobile robot composed of More >

Xinshan Zhuang^*, Shunlei Xia, Ruijie Pan

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.2, pp. 447-461, 2024, DOI:10.32604/fdmp.2023.042220

Abstract Clay, as the most common soil used for foundation fill, is widely used in various infrastructure projects. The physical and mechanical properties of clay are influenced by the pore solution environment. This study uses a GDS static/dynamic triaxial apparatus and nuclear magnetic resonance experiments to investigate the effects of cyclic loading on clay foundations. Moreover, the development of cumulative strain in clay is analyzed, and a fitting model for cumulative plastic strain is introduced by considering factors such as NaCl solution concentration, consolidation stress ratio, and cycle number. In particular, the effects of the NaCl… More >

Siham Hammid¹, Khatir Naima², Omolayo M. Ikumapayi³, Cheikh Kezrane¹, Abdelkrim Liazid⁴, Jihad Asad⁵, Mokdad Hayawi Rahman⁶, Farhan Lafta Rashid⁷, Naseer Ali Hussien⁸, Younes Menni^2,9,*

CMES-Computer Modeling in Engineering & Sciences, Vol.138, No.1, pp. 273-299, 2024, DOI:10.32604/cmes.2023.028951

Abstract The objective of this investigation is to assess the effect of obstacles on numerical heat transfer and fluid flow momentum in a rectangular microchannel (MC). Two distinct configurations were studied: one without obstacles and the other with alternating obstacles placed on the upper and lower walls. The research utilized the thermal lattice Boltzmann method (LBM), which solves the energy and momentum equations of fluids with the BGK approximation, implemented in a Python coding environment. Temperature jump and slip velocity conditions were utilized in the simulation for the MC and extended to all obstacle boundaries. The… More >