Xiaoqing Jiang^1,2,#, Pengchong Li^1,2,#, Hongchuang Liu^1,2, Wenjie Dong^1,2, Wenjing Liu^1,2, Di Wu^1,2, Jianping Xue^1,2, Fenglan Zhao^1,2,*, Yongbo Duan^1,2,*

Phyton-International Journal of Experimental Botany, Vol.95, No.1, 2026, DOI:10.32604/phyton.2026.074434 - 30 January 2026

Abstract As its tuberous alkaloids induce valuable pharmacological effects, Pinellia ternata has considerable clinical value. However, its production currently fails to meet its demand. In vitro microtuber culture, combined with salicylic acid (SA) elicitation, may provide an effective alternative to traditional field production. In this study, an in vitro P. ternata microtuber induction system was developed and used to evaluate SA-induced elicitation of alkaloid accumulation. The quality of in vitro microtubers was assessed by total alkaloid measurement, a cytotoxicity assay, and transcriptomic analysis. With or without SA treatment, P. ternata microtuber induction was achieved within 60 d using petiole-derived explants, with… More >

Herlina Marta¹, Novita Indrianti^2,*, Allifiyah Josi Nur Aziza³, Enny Sholichah⁴, Titik Budiati³, Achmat Sarifudin⁵, Yana Cahyana¹, Nandi Sukri¹, Aldila Din Pangawikan¹

Journal of Renewable Materials, Vol.14, No.1, 2026, DOI:10.32604/jrm.2025.02025-0145 - 23 January 2026

Abstract Corn starch (CS) is a renewable, biodegradable polysaccharide valued for its film-forming ability, yet native CS films exhibit low mechanical strength, high water sensitivity, and limited thermal stability. This study improves CS-based films by blending with poly(vinyl alcohol) (PVA) or glycerol (GLY) and using citric acid (CA) as a green, non-toxic cross-linker. Composite films were prepared by casting CS–PVA or CS–GLY with CA at 0%–0.20% (w/w of starch). The influence of CA on physicochemical, mechanical, optical, thermal, and water barrier properties was evaluated. CA crosslinking markedly enhanced the tensile strength, water resistance, and thermal stability More > Graphic Abstract

Rebecca H. Maggs^*, Marcus J. Brookes, Kenneth S. Rankin

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.069781 - 19 January 2026

Abstract Background: Photodynamic therapy (PDT) may eradicate residual malignant cells following sarcoma resection, through reactive oxygen species (ROS) mediated cytotoxicity, thus improve clinical outcomes. This study aims to assess the efficacy of 5-aminolevulinic acid (5-ALA) as a photosensitizer in combination with red light (RL) for PDT of bone sarcoma cells in vitro. Methods: Three bone sarcoma cell lines underwent treatment with 5-ALA and RL or sham-RL (SL). 5-ALA uptake was assessed using flow cytometry. Production of ROS was measured using CellROX Green staining and fluorescence microscopy. Cell viability was assessed using Cell Counting Kit-8 assays. Results: All cell… More >

Dongchi Cai^1,2,#, Jialin Ji^3,#, Chunhui Yang^1,*, Hong Cai^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.071152 - 30 December 2025

Abstract Metabolic reprogramming involving branched-chain amino acids (BCAAs)—leucine, isoleucine, and valine—is increasingly recognized as pivotal in cancer progression, metastasis, and immune modulation. This review comprehensively explores how cancer cells rewire BCAA metabolism to enhance proliferation, survival, and therapy resistance. Tumors manipulate BCAA uptake and catabolism via high expression of transporters like L-type amino acid transporter 1 (LAT1) and enzymes including branched chain amino acid transaminase 1(BCAT1), branched chain amino acid transaminase 2 (BCAT2), branched-chain alpha-keto acid dehydrogenase (BCKDH), and branched chain alpha-keto acid dehydrogenase kinase (BCKDK). These alterations sustain energy production, biosynthesis, redox homeostasis, and oncogenic… More >

Shenghui Su, Yu Zeng, Jiaxin Chen, Xieping Dong^*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070558 - 30 December 2025

Abstract Background: Recent studies have shown glycerolipid metabolism played an essential role in multiple tumors, however, its function in osteosarcoma is unclear. This study aimed to explore the role of glycerolipid metabolism in osteosarcoma. Methods: We conducted bioinformatics analysis using data from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database and single-cell RNA sequencing. Least Absolute Shrinkage and Selection Operator (LASSO) regression was used to identify the Glycerolipid metabolism-related genes associated with the clinical outcome of osteosarcoma. Tumor-associated macrophages (TAMs) and their interactions with immune cells were examined through single-cell analysis and co-culture experiments.… More >

Jia Yan Lim^1,2, Siti Madiha Muhammad Amir³, Roslan Yahya³, Marta Peña Fernández², Tze Chuen Yap^1,*

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-19, 2026, DOI:10.32604/cmc.2025.070707 - 09 December 2025

Abstract Additive Manufacturing, also known as 3D printing, has transformed conventional manufacturing by building objects layer by layer, with material extrusion or fused deposition modeling standing out as particularly popular. However, due to its manufacturing process and thermal nature, internal voids and pores are formed within the thermoplastic materials being fabricated, potentially leading to a decrease in mechanical properties. This paper discussed the effect of printing parameters on the porosity and the mechanical properties of the 3D printed polylactic acid (PLA) through micro-computed tomography (microCT), computational image analysis, and Charpy impact testing. The results for both… More >

Oleh Koshovyi¹, Amal D. Premarathna², Rando Tuvikene², Valdas Jakštas^3,4, Vaidotas Žvikas³, Yurii Hrytsyk⁵, Lyubov Grytsyk⁵, Andriy Grytsyk⁵, Jaan Liira⁶, Ain Raal^1,*

Phyton-International Journal of Experimental Botany, Vol.94, No.12, pp. 3991-4019, 2025, DOI:10.32604/phyton.2025.074153 - 29 December 2025

Abstract Gilia capitata Sims (Polemoniaceae) is an annual herbaceous plant widely distributed in western North America and cultivated as an ornamental flower. The detailed chemical composition and pharmacological properties of this plant have not been previously reported. This study aimed to investigate the chemical composition and pharmacological activity of aqueous-ethanolic extracts derived from different plant parts (herb, flowers, stems, roots, and fruits). HPLC analysis identified 12 phenolic compounds and 16 amino acids in the aqueous-ethanolic extracts obtained from these plant parts. The biological effects of the extracts were evaluated in vitro, including cytotoxicity, anti-inflammatory response, and wound-healing potential.… More >

Roland Mangold, Timea Teglas^*

BIOCELL, Vol.49, No.12, pp. 2239-2244, 2025, DOI:10.32604/biocell.2025.069925 - 24 December 2025

Abstract The quality of life in older adulthood is greatly influenced by cognitive aging, which in turn is affected by nutrition, especially as it relates to hippocampal function. Although the link between hippocampal function and nutrition is defined, the exact mechanics are still unknown. The commentary addresses how docosahexaenoic acid (DHA) contributes to age-related cognitive decline and may play a role in promoting neurogenesis and neuroplasticity on the molecular level. The current challenge to our understanding is to investigate how DHA influences hippocampal function and cognitive aging, which would be possible and even more detailed with More >

K. Wang^a,b,*, G. L. Lian^c, Y. F. Qiao^d

Chalcogenide Letters, Vol.22, No.10, pp. 889-904, 2025, DOI:10.15251/CL.2025.2210.889

Abstract The remediation of acid mine drainage (AMD), characterized by its high concentrations of toxic metal ions and low pH, presents a significant environmental challenge. In this study, exfoliated two-dimensional MoS_₂ nanosheets were prepared using a liquid-phase ultrasonication method and evaluated for their efficiency in removing Cd^²⁺, Cu^²⁺, and Pb^²⁺ from aqueous solutions. Detailed structural and morphological analyses confirmed that the exfoliation process significantly enhanced surface area, pore volume, and exposure of reactive sulfur sites. Through isotherm and kinetic modeling analyses, the adsorption behavior was found to align with the Langmuir model and pseudo-second-order kinetic equation, which implies More >

Lailan Ni`mah^1,*, Sri Rachmania Juliastuti², Mahfud Mahfud²

Journal of Renewable Materials, Vol.13, No.11, pp. 2169-2190, 2025, DOI:10.32604/jrm.2025.02025-0044 - 24 November 2025

Abstract This study evaluates the effectiveness of microwave technology in producing activated carbon from lemongrass waste, an underutilized agricultural byproduct. Microwave-assisted production offers faster heating, lower energy consumption, and better process control compared to conventional methods. It also enhances pore development, resulting in larger, cleaner, and more uniform pores, making the activated carbon more effective for adsorption. The microwave-assisted process significantly accelerates production, reducing the required time to just 10 min at a power of 400 W. Activated carbon derived from lemongrass waste at 400 W exhibits a water absorption capacity of 7.88%, ash content of… More > Graphic Abstract