Linpei Wang1,#, Xiaoqiu Ma2,#, Youqi Chen1, Jiahui Zhang1, Jiawei Zhang1, Wei Wang1,*, Shaojian Chen3,*
Oncologie, Vol.24, No.4, pp. 897-912, 2022, DOI:10.32604/oncologie.2022.025693
Abstract Background: MicroRNA-145-5p (miR-145-5p) reportedly inhibits hepatocellular carcinoma (HCC) by targeting
ARF6, SPATS2, CDCA3, KLF5, and NRAS, indicating that miR-145-5p plays an important role in the occurrence
and development of HCC by regulating the expression of various genes. In this study, we aimed to explore novel
downstream targets of miR-145-5p and elucidate the potential mechanism of miR-145-5p in HCC. Materials and
Methods: A bioinformatics analysis was performed to determine the clinical significance of miR-145-5p and
alpha/beta hydrolase domain-containing protein 17C (ABHD17C) in patients with HCC. The ability of Hep3B
cells to proliferate, migrate, and invade was examined after overexpression of miR-145-5p… More >
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