Juntao Yao*†, Xuan Yao‡, Tao Tian*, Xiao Fu*, Wenjuan Wang*, Suoni Li§, Tingting Shi*, Aili Suo*, Zhiping Ruan*, Hui Guo*, Kejun Nan*, Xiongwei Huo¶
Oncology Research, Vol.25, No.3, pp. 305-316, 2017, DOI:10.3727/096504016X14734149559061
Abstract ABCB5 belongs to the ATP-binding cassette (ABC) superfamily, which is recognized for playing a role in
the failure of chemotherapy. ABCB5 has also been found to be overexpressed at the transcriptional level in a
number of cancer subtypes, including breast cancer. However, the exact mechanism ABCB5 uses on cancer
cell metastasis is still unclear. In the present study, we demonstrate that ABCB5 expression was increased in
metastatic tissues when compared with nonmetastatic tissues. ABCB5 can significantly enhance metastasis and
epithelial–mesenchymal transition (EMT), while knockdown of ABCB5 inhibited these processes. Microarray
analysis indicated that ZEB1 may More >
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